The regulation of oxidative stress is an important factor in both tumour development and
responses to anticancer therapies. Many signalling pathways that are linked to …

Sphingolipid synthesis involves a highly conserved biosynthetic pathway that produces
fundamental precursors of complex sphingolipids. The final reaction involves the insertion of …

Dihydroceramides (DhCers) are a type of sphingolipids that for a long time were regarded
as biologically inactive. They are metabolic intermediates of the de novo sphingolipid …

Sphingosine kinase inhibitor (SKI) II has been reported as a dual inhibitor of sphingosine
kinases (SKs) 1 and 2 and has been extensively used to prove the involvement of SKs and …

Recently, several chemotherapeutic drugs have been repositioned in neurological diseases,
based on common biological backgrounds and the inverse comorbidity between cancer and …

Dihydrosphingolipids refer to sphingolipids early in the biosynthetic pathway that do not
contain a C4-trans-double bond in the sphingoid backbone: 3-ketosphinganine (3-ketoSph) …

Sphingolipid-mediated regulation in cancer development and treatment is largely ceramide-
centered with the complex sphingolipid metabolic pathways unfolding as attractive targets …

Sphingolipids such as ceramide, sphingosine-1-phosphate and sphingomyelin have been
emerging as bioactive lipids since ceramide was reported to play a role in human leukemia …

Fenretinide remains the most investigated retinoid compound for the prevention of cancer.
Its clinical use remains a genuine possibility due to a favourable toxicological profile and …

This review is aimed at the systematic mapping of ascorbic acid in the prevention and/or
treatment of cancer in clinical and non-clinical studies from 2011 to 2015, in order to …