CircRNAs are a class of single-stranded RNAs with covalently linked head-to-tail topology.
In the decades since its initial discovery, their biogenesis, regulation, and function have …

Introduction Poor or inconsistent adherence to daily oral pre-exposure prophylaxis (PrEP)
has emerged as a key barrier to effective HIV prevention. The advent of potent long-acting …

Abstract The Antibody Mediated Prevention trials showed that the broadly neutralizing
antibody (bnAb) VRC01 prevented acquisition of human immunodeficiency virus-1 (HIV-1) …

Inducing antiretroviral therapy (ART)-free virological control is a critical step toward a human
immunodeficiency virus type 1 (HIV-1) cure. In this phase 2a, placebo-controlled, double …

HIV-1 broadly neutralizing antibodies (bNAbs) are able to suppress viremia and prevent
infection. Their induction by vaccination is therefore a major goal. However, in contrast to …

Anti-HIV broadly neutralizing antibodies (bNAbs) offer a novel approach to treating,
preventing, or curing HIV. Pre-clinical models and clinical trials involving the passive transfer …

Abstract The Antibody Mediated Prevention (AMP) trials (NCT02716675 and
NCT02568215) demonstrated that passive administration of the broadly neutralizing …

While accurately predicting archived resistant mutations has been a significant challenge for
bNAb-based treatments, combinations of potent bNAbs against nonoverlapping epitopes …

Viral diseases represent a major public health concerns and ever-present risks for
developing into future pandemics. Antiviral antibody therapeutics, either alone or in …

Background Young women in sub-Saharan Africa continue to bear a high burden of HIV
infection. Combination anti-HIV monoclonal antibodies are a potential HIV prevention …