Impact of hyper-and hypo-uricemia on kidney function

J Miake, I Hisatome, K Tomita, T Isoyama, S Sugihara… - Biomedicines, 2023 - mdpi.com
Uric acid (UA) forms monosodium urate (MSU) crystals to exert proinflammatory actions,
thus causing gout arthritis, urolithiasis, kidney disease, and cardiovascular disease. UA is …

Gender Influence on XOR Activities and Related Pathologies: A Narrative Review

A Bolognesi, M Bortolotti, MG Battelli, L Polito - Antioxidants, 2024 - mdpi.com
Taking into account the patient's gender is the first step towards more precise and
egalitarian medicine. The gender-related divergences observed in purine catabolism and …

Hyperuricemia promotes the progression of atherosclerosis by activating endothelial cell pyroptosis via the ROS/NLRP3 pathway

B He, Q Nie, F Wang, X Wang, Y Zhou… - Journal of Cellular …, 2023 - Wiley Online Library
Hyperuricemia closely correlates with the development of atherosclerosis, but little is known
of the mechanism by which atherosclerosis progression occurs in hyperuricemia …

Novel pathological implications of serum uric acid with cardiovascular disease risk in obesity

D Wakabayashi, S Kato, M Tanaka… - Diabetes Research and …, 2023 - Elsevier
Aims This cohort study intended to elucidate the association between serum uric acid (SUA)
levels and cardiovascular disease events in Japanese patients with obesity. Methods …

Elevated serum uric acid increases the risk of ischemic stroke recurrence and its inflammatory mechanism in older adults

HY Zhu, SZ Zhao, ML Zhang, Y Wang… - Frontiers in Aging …, 2022 - frontiersin.org
Background Serum uric acid (UA) has been reported to be associated with ischemic stroke
and inflammation. However, whether or not UA is related to the recurrence of ischemic …

Serum uric acid variation and the risk of cardiovascular disease: A prospective cohort study

X Tian, S Chen, Y Zhang, X Zhang, Q Xu… - European Journal of …, 2023 - Elsevier
Background The association of serum uric acid (SUA) with cardiovascular disease (CVD) is
inconsistent and limited by a single measurement of SUA. This study aimed to investigate …

Association of serum uric acid to lymphocyte ratio, a novel inflammatory biomarker, with risk of stroke: A prospective cohort study

X Tian, P Wang, S Chen, Y Zhang… - CNS Neuroscience …, 2023 - Wiley Online Library
Abstract Main Problem Inflammation plays an important role in the pathological progress
associated with stroke. Serum uric acid (SUA) to lymphocyte ratio (ULR), a novel …

[HTML][HTML] Elevated serum uric acid was associated with pre-inflammatory state and impacted the role of HDL-C on carotid atherosclerosis

X Hu, J Liu, W Li, C Wang, G Li, Y Zhou… - Nutrition, Metabolism and …, 2022 - Elsevier
Background and aims Uric acid (UA) and high-density lipoprotein cholesterol (HDL-C) are
positively and negatively associated with atherosclerosis, respectively. UA and HDL-C are …

[HTML][HTML] Serum uric acid predicts the development of atherosclerosis in women but not in men: A ten-year cohort study in China

L Li, X Tian, Y Gao, Y Gu, K Zhang, L Li, H Wang… - Nutrition, Metabolism …, 2024 - Elsevier
Background and aim Atherosclerosis is becoming a significant health burden. Serum uric
acid (SUA) is the final enzymatic product of purine metabolism and can contribute to the …

The relationship between uric acid/albumin ratio and carotid intima-media thickness in patients with hypertension

F Şaylık, T Çınar, M Selçuk, İH Tanboğa - Arquivos Brasileiros de …, 2023 - SciELO Brasil
Background: Hypertension causes subendothelial inflammation and dysfunction in resulting
atherosclerosis. Carotid intima-media thickness (CIMT) is a useful marker of endothelial …