Therapeutic peptides: current applications and future directions

L Wang, N Wang, W Zhang, X Cheng, Z Yan… - Signal transduction and …, 2022 - nature.com
Peptide drug development has made great progress in the last decade thanks to new
production, modification, and analytic technologies. Peptides have been produced and …

Role of cardiac natriuretic peptides in heart structure and function

R Sarzani, M Allevi, C Di Pentima, P Schiavi… - International Journal of …, 2022 - mdpi.com
Cardiac natriuretic peptides (NPs), atrial NP (ANP) and B-type NP (BNP) are true hormones
produced and released by cardiomyocytes, exerting several systemic effects. Together with …

[HTML][HTML] Focus: Fluids: Natriuretic Peptides as Biomarkers: Narrative Review and Considerations in Cardiovascular and Respiratory Dysfunctions

M Samad, S Malempati, CBA Restini - The Yale Journal of Biology …, 2023 - ncbi.nlm.nih.gov
Natriuretic peptides (NPs) encompass a family of structurally related hormone/paracrine
factors acting through the natriuretic peptide system regulating cell proliferation, vessel tone …

Molecular mechanisms of sacubitril/valsartan in cardiac remodeling

NH Mustafa, J Jalil, S Zainalabidin… - Frontiers in …, 2022 - frontiersin.org
Cardiovascular diseases have become a major clinical burden globally. Heart failure is one
of the diseases that commonly emanates from progressive uncontrolled hypertension. This …

[HTML][HTML] Phloretin ameliorates heart function after myocardial infarction via NLRP3/Caspase-1/IL-1β signaling

B Li, L Xu, J Liu, M Zhou, X Jiang - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Abstract Objectives/Aims Inflammation is crucial in structural and electrical remodeling after
myocardial infarction (MI), affecting cardiac pump function and conduction pathways …

Cellular Membrane‐Engineered Nanovesicles as a Three‐Stage Booster to Target the Lesion Core

F Huang, Y Du, Y Chen, Z Qiu, Z Wang… - Advanced …, 2023 - Wiley Online Library
The lesion core is the area with the most serious injury and vigorous repair. Existing
nanocarriers are difficult to break through the targeted delivery to the lesion core for precise …

Central role of laboratory medicine in public health and patient care

P Olver, MK Bohn, K Adeli - Clinical Chemistry and Laboratory …, 2023 - degruyter.com
Clinical laboratories play a vital role in the healthcare system. Objective medical data
provided by clinical laboratories supports approximately 60–70% of clinical decisions …

NPRC deletion mitigated atherosclerosis by inhibiting oxidative stress, inflammation and apoptosis in ApoE knockout mice

C Cheng, J Zhang, X Li, F Xue, L Cao, L Meng… - … and Targeted Therapy, 2023 - nature.com
Previous studies suggested a beneficial effect of natriuretic peptides in animal models of
cardiovascular disease, but the role of natriuretic peptide receptor C (NPRC) in the …

Corin: a key mediator in sodium homeostasis, vascular remodeling, and heart failure

X Zhang, X Gu, Y Zhang, N Dong, Q Wu - Biology, 2022 - mdpi.com
Simple Summary Atrial natriuretic peptide (ANP) is an important hormone that regulates
many physiological and pathological processes, including electrolyte and body fluid …

[HTML][HTML] Preservation of cardiac functions post myocardial infarction in vivo by a phenylboric acid-grafted hyaluronic hydrogel with anti-oxidation and accelerated …

S Wang, Y Yao, T Zhou, J Xie, J Ding, W Cao… - Composites Part B …, 2022 - Elsevier
Excessive oxidative stress and inflammatory responses can exacerbate the pathological
conditions of left ventricular (LV) myocardium and even lead to heart failure post myocardial …