Megakaryocytes (MKs) are multifunctional hematopoietic cells that produce platelets, serve
as components of bone marrow (BM) niches that support the development of hematopoietic …

Background Developing the ability to use tumor-directed therapies to trigger potentially
therapeutic immune responses against cancer antigens remains a high priority for cancer …

Immunotherapy has become a standard treatment in many cancers and it is based on three
main therapeutic axes: immune checkpoint blockade (ICB), vaccination and adoptive cell …

Introduction Histotripsy is a novel focused ultrasound tumor ablation modality with potent
immunostimulatory effects. Methods To measure the spatiotemporal kinetics of local …

A variety of intrinsic and extrinsic factors contribute to the altered efficiency of CTLs in elderly
organisms. In particular, the efficacy of antiviral CD8+ T cells responses in the elderly has …

Cancer is a leading cause of death worldwide and, despite new targeted therapies and
immunotherapies, a large group of patients fail to respond to therapy or progress after initial …

Immunotherapy has revolutionized clinical outcomes in both early-stage and advanced-
stage malignancies. Immunotherapy has improved patient survival in both solid and …

Background Adoptive cancer immunotherapy, using engineered T-cells, expressing
chimeric antigen receptor or autologous tumor infiltrating lymphocytes became, in recent …

Vascular endothelial growth factor (VEGF) has important effects on hematopoietic and
immune cells. A link between VEGF expression, tumor progression, and metastasis has …

Immune checkpoint inhibitor-based immunotherapy (ICI) of breast cancer is currently
efficacious in a fraction of triple negative breast cancers (TNBC) as these cancers generally …