Histone deacetylase 11 (HDAC11) is the only member of the class IV HDAC, and the latest
member identified. It is highly expressed in brain, heart, kidney and some other organs, and …

Renal tubular epithelial cells (TECs) play a key role in kidney fibrosis by mediating cycle
arrest at G2/M. However, the key HDAC isoforms and the underlying mechanism that are …

Regular exercise training can lead to several health benefits, reduce mortality risk, and
increase life expectancy. On the other hand, a sedentary lifestyle is a known risk factor for …

Corneal wound healing requires epithelial reorganization and stromal extracellular matrix
(ECM) remodeling, with ECM proteins such as Tenascin C (TnC) regulating and maintaining …

Abstract Background and Aims No effective therapeutic intervention exists for intestinal
fibrosis in Crohn's disease [CD]. We characterized fibroblast subtypes, epigenetic and …

CKD is a global health concern with significant implications for patients' well-being,
morbidity, and mortality. The underlying mechanism of CKD development often involves …

Background Rhein can significantly delay the progression of chronic nephropathy. However,
its mechanism of action has not been adequately elaborated, which hinders its extensive …

Globally,∼ 850 million individuals suffer from some form of kidney disease. This staggering
figure underscores the importance of continued research and innovation in the field of …

Background Chemical modifications on RNA profoundly impact RNA function and
regulation. m 6 A, the most abundant RNA modification in eukaryotes, plays a pivotal role in …

Chronic kidney disease (CKD) is almost always associated with comorbidities such as
diabetes, hyperuricemia/gout, urolithiasis, often with urinary tract infection, hypertension …