The pathogenesis of Alzheimer's disease is highly complex. While several pathologies
characterize this disease, amyloid plaques, composed of the β-amyloid peptide are hallmark …

Acetylcholine is widely distributed in the nervous system and has been implicated to play a
critical role in cerebral cortical development, cortical activity, controlling cerebral blood flow …

Recent efforts have revealed that numerous protein-coding messenger RNAs have natural
antisense transcript partners, most of which seem to be noncoding RNAs. Here we identify a …

Background MicroRNAs (miRNAs) have the potential to regulate diverse sets of mRNA
targets. In addition, mammalian genomes contain numerous natural antisense transcripts …

We have created early-onset transgenic (Tg) models by exploiting the synergistic effects of
familial Alzheimer's disease mutations on amyloid β-peptide (Aβ) biogenesis. TgCRND8 …

Cognitive impairment and emotional disturbances in Alzheimer's disease (AD) result from
the degeneration of synapses and death of neurons in the limbic system and associated …

Hydroxynonenal (HNE), an aldehydic product of lipid peroxidation, up‐regulates expression
of the β‐site APP cleaving enzyme (BACE‐1), an aspartyl protease responsible for the β …

Astrocytes are the main support cells of the central nervous system. They also participate in
neuroimmune reactions. In response to pathological and immune stimuli, astrocytes …

The extracellular accumulation of amyloid‐beta (Aβ) in neuritic plaques is one of the
characteristic hallmarks of Alzheimer's disease (AD), a progressive dementing …

Degenerative dementia is mainly caused by A lzheimer's disease and/or cerebrovascular
abnormalities. Disturbance of the intracellular calcium homeostasis is central to the …