DNA methylation is an epigenetic mechanism regulating gene expression. Changes in DNA
methylation were suggested to be useful biomarkers for diagnosis, and for the determination …

Colorectal cancer (CRC) is still a leading cause of cancer death worldwide. Less than half of
cases are diagnosed when the cancer is locally advanced. CRC is a heterogenous disease …

Colorectal cancer (CRC) is one of the most common malignancies and is a major cause of
cancer-related deaths worldwide. Thus, there is a clinical need to improve early detection of …

Over the last four decades, methodological innovations have continuously changed
transcriptome profiling. It is now feasible to sequence and quantify the transcriptional outputs …

Background Better prognostic outcome is closely correlated with early detection of bladder
cancer. Current non-invasive urianalysis relies on simultaneously testing multiple …

Abstract Background and Aims Stool DNA testing is an emerging and attractive option for
colorectal cancer (CRC) screening. We previously evaluated the feasibility of a stool DNA …

Background DNA methylation biomarkers in stool may have applications in early colorectal
cancer (CRC) detection; however, their association with stages of CRC carcinogenesis or …

Background DNA-methylation-based machine learning algorithms have demonstrated
powerful diagnostic capabilities, and these tools are currently emerging in many fields of …

Simple Summary Colorectal cancer (CRC) is one of the most frequent cancers worldwide.
Early detection of CRC is crucial, as it greatly improves the survival of patients. Currently, the …

Background Aberrant DNA methylation has emerged as a class of promising biomarkers for
early colorectal cancer (CRC) detection, but the performance of methylated C9orf50 and …