[HTML][HTML] Role of the Innate Immune Response in Glomerular Disease Pathogenesis: Focus on Podocytes

W Issa, R Njeim, A Carrazco, GW Burke, A Mitrofanova - Cells, 2024 - mdpi.com
Accumulating evidence indicates that inflammatory and immunologic processes play a
significant role in the development and progression of glomerular diseases. Podocytes, the …

Membranous nephropathy treatment standard

Y Radhakrishnan, L Zand, S Sethi… - Nephrology Dialysis …, 2024 - academic.oup.com
Membranous nephropathy (MN) is characterized by deposition of immune complexes
leading to thickening of glomerular basement membranes. Over time, the understanding of …

Membranous nephropathy—diagnosis and identification of target antigens

S Sethi, FC Fervenza - Nephrology Dialysis Transplantation, 2024 - academic.oup.com
Membranous nephropathy (MN) is a common cause of nephrotic syndrome in adults. MN is
characterized by subepithelial accumulation of immune complexes along the glomerular …

Therapeutic targets in membranous nephropathy: plasma cells and complement

NM Tomas - Clinical Kidney Journal, 2024 - academic.oup.com
Membranous nephropathy (MN) is an antibody-mediated autoimmune disease and the most
common cause of nephrotic syndrome in adults. The discovery of the phospholipase A2 …

Understanding the podocyte immune responses in proteinuric kidney diseases: from pathogenesis to therapy

H Jiang, Z Shen, J Zhuang, C Lu, Y Qu, C Xu… - Frontiers in …, 2024 - frontiersin.org
The glomerular filtration barrier, comprising the inner layer of capillary fenestrated
endothelial cells, outermost podocytes, and the glomerular basement membrane between …

The Prevalence, Characteristics, and Putative Mechanisms of Dual Antigen-Positive Membranous Nephropathy: The Underestimated Condition

T Uchida, T Oda - International Journal of Molecular Sciences, 2024 - mdpi.com
Following the discovery of podocyte phospholipase A2 receptor and thrombospondin type-1
domain-containing 7A, various potential target antigens for membranous nephropathy (MN) …

Ten tips on immunosuppression in primary membranous nephropathy

H Trujillo, F Caravaca-Fontán… - Clinical Kidney Journal, 2024 - academic.oup.com
Membranous nephropathy (MN) management poses challenges, particularly in selecting
appropriate immunosuppressive treatments (IST) and monitoring disease progression and …

A reliable clinical test for detection of membranous nephropathy antigens using laser microdissection and mass spectrometry

JA Vrana, JD Theis, PJ Wegwerth, S Dasari… - Kidney International, 2024 - Elsevier
Membranous nephropathy (MN) results from accumulation of antigen-antibody immune-
complexes along the subepithelial region of the glomerular basement membranes. Over the …

Membranous nephropathy: pathogenesis and treatments

M Wang, J Yang, X Fang, W Lin, Y Yang - MedComm, 2024 - Wiley Online Library
Membranous nephropathy (MN), an autoimmune disease, can manifest at any age and is
among the most common causes of nephrotic syndrome in adults. In 80% of cases, the …

Clinicopathological characteristics of neural epidermal growth factor-like 1 protein-associated membranous glomerulonephritis

T Hyodo, S Hara, S Goto, H Fujii, S Nishi, A Yoshimoto… - Virchows Archiv, 2024 - Springer
Neural epidermal growth factor-like 1 protein (NELL1) is the second most common target
antigen in membranous glomerulonephritis (MGN). However, data regarding the …