Stress granules (SGs) are phase-separated, membraneless, cytoplasmic ribonucleoprotein
(RNP) assemblies whose primary function is to promote cell survival by condensing …

Dysregulated RNA splicing is a molecular feature that characterizes almost all tumour types.
Cancer-associated splicing alterations arise from both recurrent mutations and altered …

SARS‐CoV‐2 contains a positive single‐stranded RNA genome of approximately 30 000
nucleotides. Within this genome, 15 RNA elements were identified as conserved between …

Small molecule targeting of RNA has emerged as a new frontier in medicinal chemistry, but
compared to the protein targeting literature our understanding of chemical matter that binds …

Targeted protein degradation (TPD), represented by proteolysis-targeting chimera
(PROTAC), has emerged as a novel therapeutic modality in drug discovery. However, the …

While there is increasing interest in the study of RNA as a therapeutic target, efforts to
understand RNA-ligand recognition at the molecular level lag far behind our understanding …

Introduction The field of RNA-targeted small molecules is rapidly evolving, owing to the
advances in experimental and computational technologies. With the identification of several …

Interest in small molecules that target RNA is flourishing, and the expectation set on them to
treat diseases with unmet medical needs is high. However, several challenges remain …

Tumor immunotherapy has made great progress in cancer treatment but still faces several
challenges, such as a limited number of targetable antigens and varying responses among …

RNA targeting, specifically with small molecules, is a relatively new and rapidly emerging
avenue with the promise to expand the target space in the drug discovery field. From being …