The past decades have yielded major therapeutic advances in many autoimmune conditions–
such as multiple sclerosis (MS)–and thus ushered in a new era of more targeted and …

B cells play a pivotal role in the pathogenesis of autoimmune disease (AD) by the production
of autoantibodies, secretion of cytokines and presentation of autoantigens. As a pro-survival …

Background Changes in IgG glycosylation, as a novel pathological feature, are observed in
various autoimmune diseases (AIDs). The glycosylation patterns of IgG play a critical role in …

The meningeal space is a critical brain structure providing immunosurveillance for the
central nervous system (CNS), but the impact of infections on the meningeal immune …

Multiple sclerosis (MS) has traditionally been viewed as a chronic inflammatory disease
affecting the white matter of the central nervous system. However, over the past two …

Multiple sclerosis (MS) is a chronic autoimmune demyelinating disease of the central
nervous system (CNS) that often progresses to severe disability. Previous studies have …

This work reports the first dual magnetic beads (MBs) assisted immunoplatform for the
simultaneous determination of BAFF (B cell activation factor) and APRIL (a proliferation …

Background Elevated thyroid hormone (TH) levels have been suggested to be associated
with the pathological progression of Graves' disease (GD). However, direct evidence from …

Granulomatosis with polyangiitis (GPA) is a rare systemic ANCA (Anti-neutrophil cytoplasmic
antibodies) associated vasculitis (AAV). In the last couple of decades, GPA has emerged as …

B cells play multiple roles in immune responses related to autoimmune diseases as well as
different types of cancers. As such, strategies focused on B cell targeting attracted wide …