Strategies for enhancing cancer chemodynamic therapy performance

D Jana, Y Zhao - Exploration, 2022 - Wiley Online Library
Chemodynamic therapy (CDT) has emerged to be a frontrunner amongst reactive oxygen
species‐based cancer treatment modalities. CDT utilizes endogenous H2O2 in tumor …

Biomedical engineering of two-dimensional MXenes

H Huang, C Dong, W Feng, Y Wang, B Huang… - Advanced Drug Delivery …, 2022 - Elsevier
The emergence of two-dimensional (2D) transition metal carbides, carbonitrides and
nitrides, referred to MXenes, with a general chemical formula of M n+ 1 X n T x have aroused …

Cancer cell-mitochondria hybrid membrane coated Gboxin loaded nanomedicines for glioblastoma treatment

Y Zou, Y Sun, Y Wang, D Zhang, H Yang… - Nature …, 2023 - nature.com
Glioblastoma (GBM) remains the most lethal malignant tumours. Gboxin, an oxidative
phosphorylation inhibitor, specifically restrains GBM growth by inhibiting the activity of F0F1 …

Carbon dots supported single Fe atom nanozyme for drug-resistant glioblastoma therapy by activating autophagy-lysosome pathway

P Muhammad, S Hanif, J Li, A Guller, FU Rehman… - Nano Today, 2022 - Elsevier
Glioblastoma (GBM) is a fatal and recurrent brain cancer without any complete prevailing
remedy. Here, we explored single-atom nanozyme-mediated catalytic therapy to precisely …

Two-Dimensional MXene-Originated In Situ Nanosonosensitizer Generation for Augmented and Synergistic Sonodynamic Tumor Nanotherapy

M Zhang, D Yang, C Dong, H Huang, G Feng, Q Chen… - ACS …, 2022 - ACS Publications
Despite the merits of high tissue-penetrating depth, no ionizing radiation, and low cost,
sonodynamic therapy (SDT) still suffers from a low quantum yield of reactive oxygen species …

Brain-targeted codelivery of Bcl-2/Bcl-xl and Mcl-1 inhibitors by biomimetic nanoparticles for orthotopic glioblastoma therapy

W He, X Li, M Morsch, M Ismail, Y Liu, FU Rehman… - ACS …, 2022 - ACS Publications
Glioblastoma (GBM) is among the most treatment-resistant solid tumors and often recurrs
after resection. One of the mechanisms through which GBM escapes various treatment …

Multichannel sonocatalysis amplifiers target IDH1‐mutated tumor plasticity and attenuate ros tolerance to repress malignant cholangiocarcinoma

D Wang, X Zhu, X Wang, Q Wang, K Yan… - Advanced Functional …, 2023 - Wiley Online Library
Tumor adaptation‐originated tumor tolerance that compensatory mechanisms (eg, isocitrate
dehydrogenase (IDH) mutation) jointly shape is the dominant obstacle of ROS therapy …

Single Atom‐Doped Nanosonosensitizers for Mutually Optimized Sono/Chemo‐Nanodynamic Therapy of Triple Negative Breast Cancer

Q Chen, M Zhang, H Huang, C Dong, X Dai… - Advanced …, 2023 - Wiley Online Library
Sonodynamic therapy (SDT) represents a promising therapeutic modality for treating breast
cancer, which relies on the generation of abundant reactive oxygen species (ROS) to induce …

Photo‐facilitated chemodynamic therapeutic agents: Synthesis, mechanisms, and biomedical applications

N Yang, C Cao, X Lv, T Zhang, J Shao, X Song… - …, 2023 - Wiley Online Library
Chemodynamic therapy (CDT) utilizes Fenton and/or Fenton‐like reactions in the tumor
microenvironment (TME) to produce cytotoxic reactive oxygen species (ROS, mainly …

Tumor microenvironment-triggered intratumoral in-situ biosynthesis of inorganic nanomaterials for precise tumor diagnostics

X Zhang, Q Zhao, J Yang, T Wang, F Chen… - Coordination Chemistry …, 2023 - Elsevier
The severe side effects and low bioavailability of conventional chemotherapeutic drugs are
the major problems that current clinical cancer treatments suffer from. In recent years, tumor …