Oncolytic virotherapy: basic principles, recent advances and future directions

D Lin, Y Shen, T Liang - Signal transduction and targeted therapy, 2023 - nature.com
Oncolytic viruses (OVs) have attracted growing awareness in the twenty-first century, as they
are generally considered to have direct oncolysis and cancer immune effects. With the …

Oncolytic virus therapy for malignant gliomas: entering the new era

H Fudaba, H Wakimoto - Expert Opinion on Biological Therapy, 2023 - Taylor & Francis
Introduction To overcome the challenge of treating malignant brain tumors, oncolytic viruses
(OVs) represent an innovative therapeutic approach, featuring unique mechanisms of action …

Neoantigen-targeted TCR-engineered T cell immunotherapy: current advances and challenges

Z Pang, M Lu, Y Zhang, Y Gao, J Bai, J Gu, L Xie… - Biomarker …, 2023 - Springer
Adoptive cell therapy using T cell receptor-engineered T cells (TCR-T) is a promising
approach for cancer therapy with an expectation of no significant side effects. In the human …

Harnessing natural killer cells for lung cancer therapy

S Ma, MA Caligiuri, J Yu - Cancer Research, 2023 - AACR
Lung cancer is the leading cause of cancer-related death worldwide. Although natural killer
(NK) cells are garnering interest as a potential anticancer therapy because they selectively …

[HTML][HTML] Oncolytic herpes simplex viruses for the treatment of glioma and targeting glioblastoma stem-like cells

K Kardani, J Sanchez Gil, SD Rabkin - Frontiers in Cellular and …, 2023 - frontiersin.org
Glioblastoma (GBM) is one of the most lethal cancers, having a poor prognosis and a
median survival of only about 15 months with standard treatment (surgery, radiation, and …

Integrating innate and adaptive immunity in oncolytic virus therapy

K DePeaux, GM Delgoffe - Trends in Cancer, 2023 - cell.com
Oncolytic viruses (OVs), viruses engineered to lyse tumor cells, work hand in hand with the
immune response. While for decades the field isolated lytic capability and viral spread to …

The Cytotoxic Cardiac Glycoside (−)-Cryptanoside A from the Stems of Cryptolepis dubia and Its Molecular Targets

Y Ren, EN Kaweesa, L Tian, S Wu… - Journal of Natural …, 2023 - ACS Publications
A cardiac glycoside epoxide,(−)-cryptanoside A (1), was isolated from the stems of
Cryptolepis dubia collected in Laos, for which the complete structure was confirmed by …

[HTML][HTML] IGF2BP3 Enhances the Growth of Hepatocellular Carcinoma Tumors by Regulating the Properties of Macrophages and CD8+ T Cells in the Tumor …

L Ma, J Jiang, Q Si, C Chen, Z Duan - Journal of Clinical and …, 2023 - ncbi.nlm.nih.gov
Methods The relationship between IGF2BP3 and immune cell infiltration was analyzed using
online bioinformatics tools. Knockout of IGF2BP3 in mouse hepatoma cell line Hepa1-6 was …

Bispecific T-cell engagers and chimeric antigen receptor T-cell therapies in glioblastoma: an update

R Alsajjan, WP Mason - Current Oncology, 2023 - mdpi.com
Glioblastoma is the most common malignant primary brain tumor in adults. The prognosis is
extremely poor even with standard treatment of maximal safe resection, radiotherapy, and …

Understanding the immunosuppressive microenvironment of glioma: mechanistic insights and clinical perspectives

H Lin, C Liu, A Hu, D Zhang, H Yang, Y Mao - Journal of Hematology & …, 2024 - Springer
Glioblastoma (GBM), the predominant and primary malignant intracranial tumor, poses a
formidable challenge due to its immunosuppressive microenvironment, thereby confounding …