The emerging role of biosynthetic gene clusters in plant defense and plant interactions
G Polturak, A Osbourn - PLoS pathogens, 2021 - journals.plos.org
The plant kingdom produces a diverse array of chemicals, collectively making an estimated
105 to 106 different metabolites [1, 2]. These compounds are either known or likely to have …
105 to 106 different metabolites [1, 2]. These compounds are either known or likely to have …
Plant metabolic gene clusters in the multi-omics era
Secondary metabolism in plants gives rise to a vast array of small-molecule natural
products. The discovery of operon-like gene clusters in plants has provided a new …
products. The discovery of operon-like gene clusters in plants has provided a new …
A chromosome-level Camptotheca acuminata genome assembly provides insights into the evolutionary origin of camptothecin biosynthesis
M Kang, R Fu, P Zhang, S Lou, X Yang, Y Chen… - Nature …, 2021 - nature.com
Camptothecin and its derivatives are widely used for treating malignant tumors. Previous
studies revealed only a limited number of candidate genes for camptothecin biosynthesis in …
studies revealed only a limited number of candidate genes for camptothecin biosynthesis in …
Metabolomics and complementary techniques to investigate the plant phytochemical cosmos
Covering: up to 2021 Plants and their associated microbial communities are known to
produce millions of metabolites, a majority of which are still not characterized and are …
produce millions of metabolites, a majority of which are still not characterized and are …
Three chromosome-scale Papaver genomes reveal punctuated patchwork evolution of the morphinan and noscapine biosynthesis pathway
For millions of years, plants evolve plenty of structurally diverse secondary metabolites (SM)
to support their sessile lifestyles through continuous biochemical pathway innovation. While …
to support their sessile lifestyles through continuous biochemical pathway innovation. While …
Synthetic biology of plant natural products: From pathway elucidation to engineered biosynthesis in plant cells
X Zhu, X Liu, T Liu, Y Wang, N Ahmed, Z Li… - Plant Communications, 2021 - cell.com
Plant natural products (PNPs) are the main sources of drugs, food additives, and new
biofuels and have become a hotspot in synthetic biology. In the past two decades, the …
biofuels and have become a hotspot in synthetic biology. In the past two decades, the …
The current developments in medicinal plant genomics enabled the diversification of secondary metabolites' biosynthesis
MM Alami, Z Ouyang, Y Zhang, S Shu, G Yang… - International journal of …, 2022 - mdpi.com
Medicinal plants produce important substrates for their adaptation and defenses against
environmental factors and, at the same time, are used for traditional medicine and industrial …
environmental factors and, at the same time, are used for traditional medicine and industrial …
The Rauvolfia tetraphylla genome suggests multiple distinct biosynthetic routes for yohimbane monoterpene indole alkaloids
EA Stander, B Lehka, I Carqueijeiro, C Cuello… - Communications …, 2023 - nature.com
Monoterpene indole alkaloids (MIAs) are a structurally diverse family of specialized
metabolites mainly produced in Gentianales to cope with environmental challenges. Due to …
metabolites mainly produced in Gentianales to cope with environmental challenges. Due to …
More than a Catharanthus plant: a multicellular and pluri-organelle alkaloid-producing factory
N Kulagina, LV Méteignier, N Papon… - Current Opinion in Plant …, 2022 - Elsevier
Plants represent a huge reservoir of natural products. A broad series of these compounds
now find application for human health. In this respect, the monoterpene indole alkaloids …
now find application for human health. In this respect, the monoterpene indole alkaloids …
Plant biosynthetic gene clusters in the context of metabolic evolution
SJ Smit, BR Lichman - Natural Product Reports, 2022 - pubs.rsc.org
Covering: up to 2022 Plants produce a wide range of structurally and biosynthetically
diverse natural products to interact with their environment. These specialised metabolites …
diverse natural products to interact with their environment. These specialised metabolites …