The emerging role of biosynthetic gene clusters in plant defense and plant interactions

G Polturak, A Osbourn - PLoS pathogens, 2021 - journals.plos.org
The plant kingdom produces a diverse array of chemicals, collectively making an estimated
105 to 106 different metabolites [1, 2]. These compounds are either known or likely to have …

Plant metabolic gene clusters in the multi-omics era

C Zhan, S Shen, C Yang, Z Liu, AR Fernie… - Trends in Plant …, 2022 - cell.com
Secondary metabolism in plants gives rise to a vast array of small-molecule natural
products. The discovery of operon-like gene clusters in plants has provided a new …

A chromosome-level Camptotheca acuminata genome assembly provides insights into the evolutionary origin of camptothecin biosynthesis

M Kang, R Fu, P Zhang, S Lou, X Yang, Y Chen… - Nature …, 2021 - nature.com
Camptothecin and its derivatives are widely used for treating malignant tumors. Previous
studies revealed only a limited number of candidate genes for camptothecin biosynthesis in …

Metabolomics and complementary techniques to investigate the plant phytochemical cosmos

H Tsugawa, A Rai, K Saito, R Nakabayashi - Natural Product Reports, 2021 - pubs.rsc.org
Covering: up to 2021 Plants and their associated microbial communities are known to
produce millions of metabolites, a majority of which are still not characterized and are …

Three chromosome-scale Papaver genomes reveal punctuated patchwork evolution of the morphinan and noscapine biosynthesis pathway

X Yang, S Gao, L Guo, B Wang, Y Jia, J Zhou… - Nature …, 2021 - nature.com
For millions of years, plants evolve plenty of structurally diverse secondary metabolites (SM)
to support their sessile lifestyles through continuous biochemical pathway innovation. While …

Synthetic biology of plant natural products: From pathway elucidation to engineered biosynthesis in plant cells

X Zhu, X Liu, T Liu, Y Wang, N Ahmed, Z Li… - Plant Communications, 2021 - cell.com
Plant natural products (PNPs) are the main sources of drugs, food additives, and new
biofuels and have become a hotspot in synthetic biology. In the past two decades, the …

The current developments in medicinal plant genomics enabled the diversification of secondary metabolites' biosynthesis

MM Alami, Z Ouyang, Y Zhang, S Shu, G Yang… - International journal of …, 2022 - mdpi.com
Medicinal plants produce important substrates for their adaptation and defenses against
environmental factors and, at the same time, are used for traditional medicine and industrial …

The Rauvolfia tetraphylla genome suggests multiple distinct biosynthetic routes for yohimbane monoterpene indole alkaloids

EA Stander, B Lehka, I Carqueijeiro, C Cuello… - Communications …, 2023 - nature.com
Monoterpene indole alkaloids (MIAs) are a structurally diverse family of specialized
metabolites mainly produced in Gentianales to cope with environmental challenges. Due to …

More than a Catharanthus plant: a multicellular and pluri-organelle alkaloid-producing factory

N Kulagina, LV Méteignier, N Papon… - Current Opinion in Plant …, 2022 - Elsevier
Plants represent a huge reservoir of natural products. A broad series of these compounds
now find application for human health. In this respect, the monoterpene indole alkaloids …

Plant biosynthetic gene clusters in the context of metabolic evolution

SJ Smit, BR Lichman - Natural Product Reports, 2022 - pubs.rsc.org
Covering: up to 2022 Plants produce a wide range of structurally and biosynthetically
diverse natural products to interact with their environment. These specialised metabolites …