Traumatic brain injury: progress and challenges in prevention, clinical care, and research

AIR Maas, DK Menon, GT Manley, M Abrams… - The Lancet …, 2022 - thelancet.com
Executive summary Traumatic brain injury (TBI) has the highest incidence of all common
neurological disorders, and poses a substantial public health burden. TBI is increasingly …

The immunological response to traumatic brain injury

EJ Needham, A Helmy, ER Zanier, JL Jones… - Journal of …, 2019 - Elsevier
Traumatic brain injury (TBI) is the leading cause of death and disability in young adults in the
developed world. The accuracy of early outcome-prediction remains poor even when all …

[HTML][HTML] Blood biomarkers on admission in acute traumatic brain injury: relations to severity, CT findings and care path in the CENTER-TBI study

E Czeiter, K Amrein, BY Gravesteijn, F Lecky… - …, 2020 - thelancet.com
Background Serum biomarkers may inform and improve care in traumatic brain injury (TBI).
We aimed to correlate serum biomarkers with clinical severity, care path and imaging …

[PDF][PDF] Reducing acetylated tau is neuroprotective in brain injury

MK Shin, E Vázquez-Rosa, Y Koh, M Dhar, K Chaubey… - Cell, 2021 - cell.com
Traumatic brain injury (TBI) is the largest non-genetic, non-aging related risk factor for
Alzheimer's disease (AD). We report here that TBI induces tau acetylation (ac-tau) at sites …

Incremental prognostic value of acute serum biomarkers for functional outcome after traumatic brain injury (CENTER-TBI): an observational cohort study

IRAR Helmrich, E Czeiter, K Amrein, A Büki… - The Lancet …, 2022 - thelancet.com
Background Several studies have reported an association between serum biomarker values
and functional outcome following traumatic brain injury. We aimed to examine the …

[HTML][HTML] Serum metabolome associated with severity of acute traumatic brain injury

I Thomas, AM Dickens, JP Posti, E Czeiter… - Nature …, 2022 - nature.com
Complex metabolic disruption is a crucial aspect of the pathophysiology of traumatic brain
injury (TBI). Associations between this and systemic metabolism and their potential …

[HTML][HTML] Blood-based biomarkers of inflammation in mild traumatic brain injury: A systematic review

K Visser, M Koggel, J Blaauw, HJ van der Horn… - Neuroscience & …, 2022 - Elsevier
Abstract VISSER, K., M. Koggel, J. Blaauw, HJvd Horn, B. Jacobs, and Jvd Naalt. Blood
based biomarkers of inflammation in mild traumatic brain injury: A systematic review …

Blood biomarkers for detection of brain injury in COVID-19 patients

ST DeKosky, PM Kochanek, AB Valadka… - Journal of …, 2021 - liebertpub.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus attacks multiple
organs of coronavirus disease 2019 (COVID-19) patients, including the brain. There are …

Traumatic brain injury: classification, models, and markers

D Najem, K Rennie… - … and cell biology, 2018 - cdnsciencepub.com
Traumatic brain injury (TBI) is a leading cause of morbidity and mortality worldwide. Due to
its high incidence rate and often long-term sequelae, TBI contributes significantly to …

Glial fibrillary acidic protein elevations relate to neuroimaging abnormalities after mild TBI

J Gill, L Latour, R Diaz-Arrastia, V Motamedi, C Turtzo… - Neurology, 2018 - AAN Enterprises
Objectives To determine whether a panel of blood-based biomarkers can discriminate
between patients with suspected mild traumatic brain injury (mTBI) with and without …