Uric acid (UA) is an end product of purine metabolism in humans and great apes. UA acts as
an antioxidant and it accounts for 50% of the total antioxidant capacity of biological fluids in …

Serum uric acid is commonly elevated in subjects with chronic kidney disease (CKD), but
was historically viewed as an issue of limited interest. Recently, uric acid has been …

Uric acid, generated from the metabolism of purines, has proven and emerging roles in
human disease. Serum uric acid is determined by production and the net balance of …

Objective A novel rodent model and a recent randomized trial of hyperuricemic adolescents
with hypertension suggest a pathogenetic role of uric acid in hypertension, but it remains …

Hyperuricaemia is common in subjects with cardiovascular disease, but is not commonly
considered a true risk factor. Recent studies suggest that uric acid is biologically active and …

In recent years, the focus of interest on the role of the renin-angiotensin system (RAS) in the
pathophysiology of hypertension and organ injury has changed to a major emphasis on the …

Background Plasma uric acid has been associated with hypertension in a variety of
disorders, and has been shown to be predictive of hypertension. The mechanistic role of uric …

Objective Serum uric acid (SUA) levels have been used to predict cardiovascular and all-
cause mortality event, but the data have yielded conflicting results. We investigated whether …

Altered serum uric acid concentrations, both above and below normal levels, have been
linked to a number of disease states. An abnormally high uric acid level has been correlated …

Endothelial dysfunction is a characteristic feature during the renal damage induced by mild
hyperuricemia. The mechanism by which uric acid reduces the bioavailability of intrarenal …