Elevated serum uric acid (SUA) levels may increase the risk of prehypertension. However,
the findings from these studies remain conflicting. The objective of this study was to …

Background and aims Uric acid, the end-product of human purine metabolism, is associated
with hypertension, diabetes and obesity. It has also been independently associated with the …

Hyperuricemia (HUA) is positively correlated with the progression of cardiovascular and
metabolic diseases. Anti-HUA drugs aim to either reduce uric acid production or promote …

Objective: The association of serum uric acid (SUA) with risk of hypertension is controversial
and may be modulated by lifestyle factors. We did a prospective study to investigate whether …

Hyperuricemia is associated with increases in cardiovascular risk and renal disease.
Mesangial cells regulate glomerular filtration rates through the release of hormones and …

Aims Increased plasma uric acid (PUA) levels are associated with impaired renal function in
patients with Type 1 diabetes, but the mechanisms are not well understood. Our aim was to …

The current study aimed to investigate the molecular mechanisms of metformin and vitamin
D3-induced nephroprotection in a metabolic syndrome (MetS) rat model, evaluating the …

Abstract Purpose of Review Multiple experimental and clinical studies have identified
pathways by which uric acid may facilitate the development and progression of chronic …

The purpose of this study is to investigate the effect of urate-lowering therapies (ULTs) on
renal uric acid excretion in gout patients. This prospective observational study involved 106 …

Background A correlation between hyperuricemia and renal target organ damage (TOD)
was shown in hypertensive patients, locally mediated by the activation of renin–angiotensin …