Targeting epigenetic and posttranslational modifications regulating ferroptosis for the treatment of diseases

Y Wang, J Hu, S Wu, JS Fleishman, Y Li, Y Xu… - … and Targeted Therapy, 2023 - nature.com
Ferroptosis, a unique modality of cell death with mechanistic and morphological differences
from other cell death modes, plays a pivotal role in regulating tumorigenesis and offers a …

Ischemia/reperfusion injury following acute myocardial infarction: a critical issue for clinicians and forensic pathologists

M Neri, I Riezzo, N Pascale, C Pomara… - Mediators of …, 2017 - Wiley Online Library
Acute myocardial infarction (AMI) is a leading cause of morbidity and mortality. Reperfusion
strategies are the current standard therapy for AMI. However, they may result in paradoxical …

M2 macrophage-derived exosomes carry microRNA-148a to alleviate myocardial ischemia/reperfusion injury via inhibiting TXNIP and the TLR4/NF-κB/NLRP3 …

Y Dai, S Wang, S Chang, D Ren, S Shali, C Li… - Journal of molecular and …, 2020 - Elsevier
Background Reperfusion may cause injuries to the myocardium in ischemia situation.
Emerging studies suggest that exosomes may serve as key mediators in myocardial …

Therapeutic applications of adipose cell-free derivatives: a review

Y Cai, J Li, C Jia, Y He, C Deng - Stem Cell Research & Therapy, 2020 - Springer
Background Adipose-derived stem cells (ADSCs) have become one of the most utilized
adult stem cells due to their abundance and accessibility. Recent studies have shown that …

Phytochemistry and cardiovascular protective effects of Huang‐Qi (Astragali Radix)

H Su, S Shaker, Y Kuang, M Zhang… - Medicinal Research …, 2021 - Wiley Online Library
Abstract Huang‐Qi (Astragali Radix) is an herbal tonic widely used in China and many other
countries. It is derived from the roots of Astragalus membranaceus and A. membranaceus …

An overview of the molecular mechanisms associated with myocardial ischemic injury: state of the art and translational perspectives

L Schirone, M Forte, L D'Ambrosio, V Valenti… - Cells, 2022 - mdpi.com
Cardiovascular disease is the leading cause of death in western countries. Among
cardiovascular diseases, myocardial infarction represents a life-threatening condition …

Hirsutine, an emerging natural product with promising therapeutic benefits: a systematic review

MS Bhuia, P Wilairatana, J Ferdous, R Chowdhury… - Molecules, 2023 - mdpi.com
Fruits and vegetables are used not only for nutritional purposes but also as therapeutics to
treat various diseases and ailments. These food items are prominent sources of …

Mesenchymal stem cell-derived exosomal microRNA-182-5p alleviates myocardial ischemia/reperfusion injury by targeting GSDMD in mice

R Yue, S Lu, Y Luo, J Zeng, H Liang, D Qin… - Cell death …, 2022 - nature.com
Recent evidence indicates that exosomes derived from mesenchymal stem cells (MSCs)
confer protective effects against myocardial ischemia/reperfusion (I/R) injury. Exosomes are …

Ferroptosis in heart failure

X Yang, NK Kawasaki, J Min, T Matsui… - Journal of molecular and …, 2022 - Elsevier
With its complicated pathobiology and pathophysiology, heart failure (HF) remains an
increasingly prevalent epidemic that threatens global human health. Ferroptosis is a form of …

The role of Nrf2 in cardiovascular function and disease

S Satta, AM Mahmoud, FL Wilkinson… - Oxidative medicine …, 2017 - Wiley Online Library
Free radicals, reactive oxygen/nitrogen species (ROS/RNS), hydrogen sulphide, and
hydrogen peroxide play an important role in both intracellular and intercellular signaling; …