The application of artificial intelligence (AI) is accelerating the paradigm shift towards patient-
tailored brain tumor management, achieving optimal onco-functional balance for each …

Glioblastomas are the most common IDH-wildtype adult high-grade gliomas, frequently
harboring mutations in the TERT gene promoter (pTERT) and utilizing the subsequent …

Background Targeted therapies have substantially improved survival in cancer patients with
malignancies outside the brain. Whether in-depth analysis for molecular alterations may …

Background Endocrine deficiencies, including hypothalamic-pituitary-gonadal axis (HPGA)
impairment, are common in survivors of childhood and adolescent medulloblastoma. Still …

The conventional computational approaches to investigating a disease confront inherent
constraints as they often need to improve in delving beyond protein functional associations …

Background In neuro-oncology, the inclusion of tumor patients in the molecular tumor board
has only become increasingly widespread in recent years, but so far there are no standards …

The concept of precision oncology, the application of targeted drugs based on
comprehensive molecular profiling, has revolutionized treatment strategies in oncology. This …

The most prevalent and aggressive subtype of intrinsic brain tumors in adults is high grade
glioma also called glioblastoma (GBM), which presents a considerable barrier for …

Background. Glioblastomas, the most common primary malignant brain tumors, are
considered immunologically cold malignancies due to growth in an immune sanctuary site …