The aging process is driven by multiple mechanisms that lead to changes in energy
production, oxidative stress, homeostatic dysregulation and eventually to loss of functionality …

The risks of heart diseases are significantly modulated by age and sex, but how these
factors influence baseline cardiac gene expression remains incompletely understood. Here …

Sex differences are prevalent in multiple mental disorders. Internalizing disorders are more
commonly diagnosed in women, whereas externalizing and neurodevelopmental disorders …

Despite extensive sex differences in human complex traits and disease, the male and
female genomes differ only in the sex chromosomes. This implies that most sex …

Sex differences in the prevalence of psychiatric disorders are well documented, with
exposure to stress during gestation differentially impacting females and males. We explored …

Epidemiology studies demonstrate that women are at a significantly lower risk of developing
type 2 diabetes (T2D) compared to men. However, the molecular basis of this risk difference …

A bulk of literature demonstrated that respiratory allergy, and especially asthma, is prevalent
in males during childhood, while it becomes more frequent in females from adolescence, ie …

In multi-cellular organisms, the control of gene expression is key not only for development,
but also for adult cellular homeostasis, and gene expression has been observed to be …

In mammals, sex chromosomes start to program autosomal gene expression and epigenetic
patterns very soon after fertilization. Yet whether the resulting sex differences are …

Nearly all human complex traits and diseases exhibit some degree of sex differences, with
epigenetics being one of the main contributing factors. Various tissues display sex …