Summary (Macro) autophagy is a fundamental degradation process for macromolecules and
organelles of vital importance for cell and tissue homeostasis. Autophagy research has …

Mounting evidence suggests that autophagy is a more selective process than originally
anticipated. The discovery and characterization of autophagic adapters, like p62 and NBR1 …

Macroautophagy (hereafter referred to as autophagy) is a catabolic membrane trafficking
process that degrades a variety of cellular constituents and is associated with human …

Cell death is a fundamental process in cardiac pathologies. Recent studies have revealed
multiple forms of cell death, and several of them have been demonstrated to underlie …

Autophagy is a fundamental function of eukaryotic cells and is well conserved from yeast to
humans. The most remarkable feature of autophagy is the synthesis of double membrane …

Autophagy, a critical process for bulk degradation of proteins and organelles, requires
conjugation of Atg8 proteins to phosphatidylethanolamine on the autophagic membrane. At …

Autophagy-related (Atg) proteins are eukaryotic factors participating in various stages of the
autophagic process. Thus far 34 Atgs have been identified in yeast, including the key …

Recognition of injured mitochondria for degradation by macroautophagy is essential for
cellular health, but the mechanisms remain poorly understood. Cardiolipin is an inner …

Two major pathways degrade most cellular proteins in eukaryotic cells: the ubiquitin–
proteasome system (UPS), which usually degrades the majority of proteins, and autophagy …

Autophagy is an essential catabolic pathway which sequesters and engulfs cytosolic
substrates via autophagosomes, unique double-membraned structures. ATG8 proteins are …