The understanding of the pathogenesis of psoriasis vulgaris has advanced significantly
since the therapeutic efficacy of immunosuppressive drugs has drawn attention to the role of …

Dominant tolerance is mediated by regulatory T cells (T reg) that control harmful
autoimmune T cells in the periphery. In this study, we investigate the implication of T reg in …

Recent results have added new information to our understanding of a~ 8 T-cell receptor
mediated recognition. In particular, we find that the V (D) J junction or'CDR3'portion of TCRa …

To examine T cell receptor (TCR) diversity involved in the memory response to a persistent
human pathogen, we determined nucleotide sequences encoding TCR-alpha and-beta …

The major histocompatibility complex class I-restricted cytotoxic T lymphocyte (CTL)
response is important in the clearance of viral infections in humans. After influenza A …

Two unusual characteristics of the memory response to the immunodominant Epstein-Barr
virus (EBV) epitope FLRGRAYGL, which associates with HLA B8, have provided an unique …

Previous studies have analyzed the diversity of T cell responses upon immunization. Little is
known, however, about the individual variability of naive repertoires and its influence on …

Infection of BALB/c mice with Listeria monocytogenes primes CD8+ cytotoxic T cells specific
for four different H2-K d-restricted peptides. In vitro restimulation of L. monocytogenes …

Activating and inhibitory CD94/NKG2 receptors regulate CTL responses by altering TCR
signaling, thus modifying antigen activation thresholds set during thymic selection. To …

Background Cytotoxic T cell (CTL) cross-reactivity is believed to play a pivotal role in
generating immune responses but the extent and mechanisms of CTL cross-reactivity …