SOTIP is a versatile method for microenvironment modeling with spatial omics data

Z Yuan, Y Li, M Shi, F Yang, J Gao, J Yao… - Nature …, 2022 - nature.com
The rapidly developing spatial omics generated datasets with diverse scales and modalities.
However, most existing methods focus on modeling dynamics of single cells while ignore …

Rethinking the initial changes in subarachnoid haemorrhage: focusing on real-time metabolism during early brain injury

Y Chen, I Galea, RL Macdonald, GKC Wong… - …, 2022 - thelancet.com
Over the last two decades, neurological researchers have uncovered many
pathophysiological mechanisms associated with subarachnoid haemorrhage (SAH), with …

Advancements in ToF-SIMS imaging for life sciences

F Jia, X Zhao, Y Zhao - Frontiers in Chemistry, 2023 - frontiersin.org
In the last 2 decades, Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) has
gained significant prominence as a powerful imaging technique in the field of life sciences …

Advances and challenges in spatial transcriptomics for developmental biology

K Choe, U Pak, Y Pang, W Hao, X Yang - Biomolecules, 2023 - mdpi.com
Development from single cells to multicellular tissues and organs involves more than just the
exact replication of cells, which is known as differentiation. The primary focus of research …

Microlensed fiber allows subcellular imaging by laser-based mass spectrometry

Y Meng, W Hang, RN Zare - Nature Protocols, 2023 - nature.com
Mass spectrometry imaging (MSI) enables the chemical mapping of molecules and elements
in a label-free, high-throughput manner. Because this approach can be accomplished …

Metabolic regulation of the hallmarks of stem cell biology

BT Jackson, LWS Finley - Cell stem cell, 2024 - cell.com
Stem cells perform many different functions, each of which requires specific metabolic
adaptations. Over the past decades, studies of pluripotent and tissue stem cells have …

Metabolic control of innate lymphoid cells in health and disease

L Zhou, Q Lin, GF Sonnenberg - Nature metabolism, 2022 - nature.com
Innate lymphoid cells (ILCs) are a family of predominantly tissue-resident lymphocytes that
critically orchestrate immunity, inflammation, tolerance and repair at barrier surfaces of the …

The interaction between ageing and Alzheimer's disease: insights from the hallmarks of ageing

Y Liu, Y Tan, Z Zhang, M Yi, L Zhu, W Peng - Translational …, 2024 - Springer
Ageing is a crucial risk factor for Alzheimer's disease (AD) and is characterised by systemic
changes in both intracellular and extracellular microenvironments that affect the entire body …

Harnessing computational spatial omics to explore the spatial biology intricacies

Z Yuan, J Yao - Seminars in Cancer Biology, 2023 - Elsevier
Spatially resolved transcriptomics (SRT) has unlocked new dimensions in our
understanding of intricate tissue architectures. However, this rapidly expanding field …

Mapping breast cancer microenvironment through single-cell omics

Z Tan, C Kan, M Sun, F Yang, M Wong… - Frontiers in …, 2022 - frontiersin.org
Breast cancer development and progression rely not only on the proliferation of neoplastic
cells but also on the significant heterogeneity in the surrounding tumor microenvironment. Its …