Singlecell analysis enables the measurement of biomolecules at the level of individual
cells, facilitating indepth investigations into cellular heterogeneity and precise interpretation …

The unique architecture of the liver allows for spatial compartmentalization of its functions,
also known as liver zonation. In contrast to organelles and cells, this compartment is devoid …

Single-cell mass spectrometry (MS) is an essential technology for sensitive and multiplexed
analysis of metabolites and lipids for cell phenotyping and pathway studies. However, the …

Over the last decade, immunometabolism has emerged as a novel interdisciplinary field of
research and yielded significant fundamental insights into the regulation of immune …

Tumors are spatially heterogeneous tissues that comprise numerous cell types with intricate
structures. By interacting with the microenvironment, tumor cells undergo dynamic changes …

Liver fibrogenesis is a highly dynamic and complex process that drives the progression of
chronic liver disease toward liver failure and end-stage liver diseases. Despite decades of …

Hepatocytes work in highly structured, repetitive hepatic lobules. Blood flow across the
radial axis of the lobule generates oxygen, nutrient, and hormone gradients, which result in …

Improved throughput of analysis and lowered limits of detection have allowed single-cell
chemical analysis to go beyond the detection of a few molecules in such volume-limited …

Spatial transcriptomics, which is capable of both measuring all gene activity in a tissue
sample and mapping where this activity occurs, is vastly improving our understanding of …

Cellular heterogeneity is essential for the physiological functions of organisms, and precise
interpretation of the relevant biological mechanisms involved requires accurate …