Targeting fibrosis: Mechanisms and clinical trials

M Zhao, L Wang, M Wang, S Zhou, Y Lu… - Signal transduction and …, 2022 - nature.com
Fibrosis is characterized by the excessive extracellular matrix deposition due to
dysregulated wound and connective tissue repair response. Multiple organs can develop …

[HTML][HTML] Pathobiology of transforming growth factor β in cancer, fibrosis and immunologic disease, and therapeutic considerations

GJ Prud'Homme - Laboratory investigation, 2007 - Elsevier
Transforming growth factor β (TGF-β) is a highly pleiotropic cytokine that plays an important
role in wound healing, angiogenesis, immunoregulation and cancer. The cells of the …

[HTML][HTML] Strategies for anti-fibrotic therapies

J Rosenbloom, FA Mendoza, SA Jimenez - Biochimica et Biophysica Acta …, 2013 - Elsevier
The fibrotic diseases encompass a wide spectrum of entities including such multisystemic
diseases as systemic sclerosis, nephrogenic systemic fibrosis and sclerodermatous graft …

Pirfenidone attenuates bleomycin-induced pulmonary fibrosis in mice by regulating Nrf2/Bach1 equilibrium

Y Liu, F Lu, L Kang, Z Wang, Y Wang - BMC pulmonary medicine, 2017 - Springer
Background Oxidative stress is one of the important factors involved in the pathogenesis of
idiopathic pulmonary fibrosis (IPF). The equilibrium of Nuclear factor-erythroid-related factor …

Narrative review: fibrotic diseases: cellular and molecular mechanisms and novel therapies

J Rosenbloom, SV Castro… - Annals of internal medicine, 2010 - acpjournals.org
Abnormal and exaggerated deposition of extracellular matrix is the hallmark of many fibrotic
diseases, including systemic sclerosis and pulmonary, liver, and kidney fibrosis. The …

Invasive intraneural interfaces: foreign body reaction issues

F Lotti, F Ranieri, G Vadalà, L Zollo… - Frontiers in …, 2017 - frontiersin.org
Intraneural interfaces are stimulation/registration devices designed to couple the peripheral
nervous system (PNS) with the environment. Over the last years, their use has increased in a …

Neferine, a bisbenzylisoquinline alkaloid attenuates bleomycin-induced pulmonary fibrosis

L Zhao, X Wang, Q Chang, J Xu, Y Huang… - European journal of …, 2010 - Elsevier
In this study, we evaluated the potential anti-fibrotic property of neferine, a
bisbenzylisoquinline alkaloid extracted from the seed embryo of Nelumbo mucifera Gaertn …

Danggui Buxue Tang Ameliorates Bleomycin‐Induced Pulmonary Fibrosis by Suppressing the TLR4/NLRP3 Signaling Pathway in Rats

J Wang, H Wang, F Fang, C Fang… - Evidence‐Based …, 2021 - Wiley Online Library
Objective. To investigate the effects of Danggui Buxue Tang (DBT) on rats with pulmonary
fibrosis (PF) and the underlying mechanism. Methods. Sixty specific pathogen‐free (SPF) …

Pirfenidone: an anti-fibrotic therapy for progressive kidney disease

ME Cho, JB Kopp - Expert opinion on investigational drugs, 2010 - Taylor & Francis
Importance of the field: Many chronic diseases of various etiologies lead to fibrosis and
organ dysfunction. Despite many advances in medicine in recent years, options to slow the …

The role of infected epithelial cells in Chlamydia-associated fibrosis

LT Caven, RA Carabeo - Frontiers in Cellular and Infection …, 2023 - frontiersin.org
Ocular, genital, and anogenital infection by the obligate intracellular pathogen Chlamydia
trachomatis have been consistently associated with scar-forming sequelae. In cases of …