Impact of air pollution on asthma outcomes
AI Tiotiu, P Novakova, D Nedeva… - International journal of …, 2020 - mdpi.com
Asthma is a chronic respiratory disease characterized by variable airflow obstruction,
bronchial hyperresponsiveness, and airway inflammation. Evidence suggests that air …
bronchial hyperresponsiveness, and airway inflammation. Evidence suggests that air …
The tobacco smoke component, acrolein, as a major culprit in lung diseases and respiratory cancers: Molecular mechanisms of acrolein cytotoxic activity
P Hikisz, D Jacenik - Cells, 2023 - mdpi.com
Acrolein, a highly reactive unsaturated aldehyde, is a ubiquitous environmental pollutant
that seriously threatens human health and life. Due to its high reactivity, cytotoxicity and …
that seriously threatens human health and life. Due to its high reactivity, cytotoxicity and …
Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis
Background The genetic risk factors for susceptibility to chronic obstructive pulmonary
disease (COPD) are still largely unknown. Additional genetic variants are likely to be …
disease (COPD) are still largely unknown. Additional genetic variants are likely to be …
Smoking and asthma: dangerous liaisons
R Polosa, NC Thomson - European respiratory journal, 2013 - Eur Respiratory Soc
Cigarette smoking and asthma interact to induce important adverse effects on clinical,
prognostic and therapeutic outcomes. This review examines recent evidence on the harmful …
prognostic and therapeutic outcomes. This review examines recent evidence on the harmful …
Treatment options in type-2 low asthma
TSC Hinks, SJ Levine… - European Respiratory …, 2021 - Eur Respiratory Soc
Monoclonal antibodies targeting IgE or the type-2 cytokines interleukin (IL)-4, IL-5 and IL-13
are proving highly effective in reducing exacerbations and symptoms in people with severe …
are proving highly effective in reducing exacerbations and symptoms in people with severe …
The role of airway epithelial cells and innate immune cells in chronic respiratory disease
MJ Holtzman, DE Byers, J Alexander-Brett… - Nature Reviews …, 2014 - nature.com
An abnormal immune response to environmental agents is generally thought to be
responsible for causing chronic respiratory diseases, such as asthma and chronic …
responsible for causing chronic respiratory diseases, such as asthma and chronic …
[HTML][HTML] Multidimensional endotyping in patients with severe asthma reveals inflammatory heterogeneity in matrix metalloproteinases and chitinase 3–like protein 1
Background Disease heterogeneity in patients with severe asthma and its relationship to
inflammatory mechanisms remain poorly understood. Objective We aimed to identify and …
inflammatory mechanisms remain poorly understood. Objective We aimed to identify and …
Role of proteases in chronic obstructive pulmonary disease
Chronic obstructive pulmonary disease (COPD) is generally associated with progressive
destruction of airways and lung parenchyma. Various factors play an important role in the …
destruction of airways and lung parenchyma. Various factors play an important role in the …
[HTML][HTML] Identification and treatment of T2-low asthma in the era of biologics
C Kyriakopoulos, A Gogali, K Bartziokas… - ERJ Open …, 2021 - Eur Respiratory Soc
Currently, and based on the development of relevant biologic therapies, T2-high is the most
well-defined endotype of asthma. Although much progress has been made in elucidating T2 …
well-defined endotype of asthma. Although much progress has been made in elucidating T2 …
Relationship between pulmonary matrix metalloproteinases and quantitative CT markers of small airways disease and emphysema in COPD
Background Matrix metalloproteinases (MMPs) are proteolytic enzymes that can degrade
the extracellular matrix and drive tissue remodelling, key processes in the pathogenesis of …
the extracellular matrix and drive tissue remodelling, key processes in the pathogenesis of …