[HTML][HTML] Metformin: update on mechanisms of action and repurposing potential
Currently, metformin is the first-line medication to treat type 2 diabetes mellitus (T2DM) in
most guidelines and is used daily by> 200 million patients. Surprisingly, the mechanisms …
most guidelines and is used daily by> 200 million patients. Surprisingly, the mechanisms …
[HTML][HTML] Metformin: Is it a drug for all reasons and diseases?
CR Triggle, I Mohammed, K Bshesh, I Marei, K Ye… - Metabolism, 2022 - Elsevier
Metformin was first used to treat type 2 diabetes in the late 1950s and in 2022 remains the
first-choice drug used daily by approximately 150 million people. An accumulation of …
first-choice drug used daily by approximately 150 million people. An accumulation of …
[HTML][HTML] Benefits of metformin in attenuating the hallmarks of aging
AS Kulkarni, S Gubbi, N Barzilai - Cell metabolism, 2020 - cell.com
Biological aging involves an interplay of conserved and targetable molecular mechanisms,
summarized as the hallmarks of aging. Metformin, a biguanide that combats age-related …
summarized as the hallmarks of aging. Metformin, a biguanide that combats age-related …
[HTML][HTML] Mitochondrial adaptation in cancer drug resistance: prevalence, mechanisms, and management
Drug resistance represents a major obstacle in cancer management, and the mechanisms
underlying stress adaptation of cancer cells in response to therapy-induced hostile …
underlying stress adaptation of cancer cells in response to therapy-induced hostile …
Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus
Despite its position as the first-line drug for treatment of type 2 diabetes mellitus, the
mechanisms underlying the plasma glucose level-lowering effects of metformin (1, 1 …
mechanisms underlying the plasma glucose level-lowering effects of metformin (1, 1 …
Obesity and cancer risk: Emerging biological mechanisms and perspectives
Continuously rising trends in obesity-related malignancies render this disease spectrum a
public health priority. Worldwide, the burden of cancer attributable to obesity, expressed as …
public health priority. Worldwide, the burden of cancer attributable to obesity, expressed as …
[HTML][HTML] The mechanisms of action of metformin
Metformin is a widely-used drug that results in clear benefits in relation to glucose
metabolism and diabetes-related complications. The mechanisms underlying these benefits …
metabolism and diabetes-related complications. The mechanisms underlying these benefits …
[HTML][HTML] Metformin and cancer hallmarks: shedding new lights on therapeutic repurposing
Y Hua, Y Zheng, Y Yao, R Jia, S Ge… - Journal of Translational …, 2023 - Springer
Metformin is a well-known anti-diabetic drug that has been repurposed for several emerging
applications, including as an anti-cancer agent. It boasts the distinct advantages of an …
applications, including as an anti-cancer agent. It boasts the distinct advantages of an …
Transcription factor NRF2 as a therapeutic target for chronic diseases: a systems medicine approach
Systems medicine has a mechanism-based rather than a symptom-or organ-based
approach to disease and identifies therapeutic targets in a nonhypothesis-driven manner. In …
approach to disease and identifies therapeutic targets in a nonhypothesis-driven manner. In …
Organic cation transporters in health and disease
H Koepsell - Pharmacological reviews, 2020 - ASPET
The organic cation transporters (OCTs) OCT1, OCT2, OCT3, novel OCT (OCTN) 1, OCTN2,
multidrug and toxin exclusion (MATE) 1, and MATE kidney-specific 2 are polyspecific …
multidrug and toxin exclusion (MATE) 1, and MATE kidney-specific 2 are polyspecific …