Methods and applications for single-cell and spatial multi-omics
K Vandereyken, A Sifrim, B Thienpont… - Nature Reviews Genetics, 2023 - nature.com
The joint analysis of the genome, epigenome, transcriptome, proteome and/or metabolome
from single cells is transforming our understanding of cell biology in health and disease. In …
from single cells is transforming our understanding of cell biology in health and disease. In …
Regulation and functions of non-m6A mRNA modifications
Nucleobase modifications are prevalent in eukaryotic mRNA and their discovery has
resulted in the emergence of epitranscriptomics as a research field. The most abundant …
resulted in the emergence of epitranscriptomics as a research field. The most abundant …
RNA modifications in physiology and disease: towards clinical applications
The ability of chemical modifications of single nucleotides to alter the electrostatic charge,
hydrophobic surface and base pairing of RNA molecules is exploited for the clinical use of …
hydrophobic surface and base pairing of RNA molecules is exploited for the clinical use of …
m6A modification: recent advances, anticancer targeted drug discovery and beyond
LJ Deng, WQ Deng, SR Fan, MF Chen, M Qi, WY Lyu… - Molecular cancer, 2022 - Springer
Abstract Abnormal N6-methyladenosine (m6A) modification is closely associated with the
occurrence, development, progression and prognosis of cancer, and aberrant m6A …
occurrence, development, progression and prognosis of cancer, and aberrant m6A …
RNA modifications: importance in immune cell biology and related diseases
L Cui, R Ma, J Cai, C Guo, Z Chen, L Yao… - Signal transduction and …, 2022 - nature.com
RNA modifications have become hot topics recently. By influencing RNA processes,
including generation, transportation, function, and metabolization, they act as critical …
including generation, transportation, function, and metabolization, they act as critical …
Vascular mechanotransduction
This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …
Molecular mechanisms of environmental exposures and human disease
A substantial proportion of disease risk for common complex disorders is attributable to
environmental exposures and pollutants. An appreciation of how environmental pollutants …
environmental exposures and pollutants. An appreciation of how environmental pollutants …
MYC-targeted WDR4 promotes proliferation, metastasis, and sorafenib resistance by inducing CCNB1 translation in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide.
However, there still remains a lack of effective diagnostic and therapeutic targets for this …
However, there still remains a lack of effective diagnostic and therapeutic targets for this …
Direct epitranscriptomic regulation of mammalian translation initiation through N4-acetylcytidine
Summary mRNA function is influenced by modifications that modulate canonical nucleobase
behavior. We show that a single modification mediates distinct impacts on mRNA translation …
behavior. We show that a single modification mediates distinct impacts on mRNA translation …
N‐acetyltransferase 10 promotes colon cancer progression by inhibiting ferroptosis through N4‐acetylation and stabilization of ferroptosis suppressor protein 1 (FSP1) …
X Zheng, Q Wang, Y Zhou, D Zhang… - Cancer …, 2022 - Wiley Online Library
Abstract Background N‐acetyltransferase 10 (NAT10) is the only enzyme known to mediate
the N4‐acetylcytidine (ac4C) modification of mRNA and is crucial for mRNA stability and …
the N4‐acetylcytidine (ac4C) modification of mRNA and is crucial for mRNA stability and …