Artificial intelligence in cancer research and precision medicine

B Bhinder, C Gilvary, NS Madhukar, O Elemento - Cancer discovery, 2021 - AACR
Artificial intelligence (AI) is rapidly reshaping cancer research and personalized clinical
care. Availability of high-dimensionality datasets coupled with advances in high …

[PDF][PDF] How machine learning will transform biomedicine

J Goecks, V Jalili, LM Heiser, JW Gray - Cell, 2020 - cell.com
This Perspective explores the application of machine learning toward improved diagnosis
and treatment. We outline a vision for how machine learning can transform three broad …

[PDF][PDF] Predicting drug response and synergy using a deep learning model of human cancer cells

BM Kuenzi, J Park, SH Fong, KS Sanchez, J Lee… - Cancer cell, 2020 - cell.com
Most drugs entering clinical trials fail, often related to an incomplete understanding of the
mechanisms governing drug response. Machine learning techniques hold immense promise …

Convolutional neural network models for cancer type prediction based on gene expression

M Mostavi, YC Chiu, Y Huang, Y Chen - BMC medical genomics, 2020 - Springer
Background Precise prediction of cancer types is vital for cancer diagnosis and therapy.
Through a predictive model, important cancer marker genes can be inferred. Several studies …

Machine learning towards intelligent systems: applications, challenges, and opportunities

MN Injadat, A Moubayed, AB Nassif… - Artificial Intelligence …, 2021 - Springer
The emergence and continued reliance on the Internet and related technologies has
resulted in the generation of large amounts of data that can be made available for analyses …

Machine learning in oncology: a clinical appraisal

R Cuocolo, M Caruso, T Perillo, L Ugga, M Petretta - Cancer letters, 2020 - Elsevier
Abstract Machine learning (ML) is a branch of artificial intelligence centered on algorithms
which do not need explicit prior programming to function but automatically learn from …

[PDF][PDF] A deep learning framework for predicting response to therapy in cancer

T Sakellaropoulos, K Vougas, S Narang, F Koinis… - Cell reports, 2019 - cell.com
A major challenge in cancer treatment is predicting clinical response to anti-cancer drugs on
a personalized basis. Using a pharmacogenomics database of 1,001 cancer cell lines, we …

Drug ranking using machine learning systematically predicts the efficacy of anti-cancer drugs

H Gerdes, P Casado, A Dokal, M Hijazi… - Nature …, 2021 - nature.com
Artificial intelligence and machine learning (ML) promise to transform cancer therapies by
accurately predicting the most appropriate therapies to treat individual patients. Here, we …

Deep learning for drug response prediction in cancer

D Baptista, PG Ferreira, M Rocha - Briefings in bioinformatics, 2021 - academic.oup.com
Predicting the sensitivity of tumors to specific anti-cancer treatments is a challenge of
paramount importance for precision medicine. Machine learning (ML) algorithms can be …

Machine and deep learning approaches for cancer drug repurposing

NT Issa, V Stathias, S Schürer… - Seminars in cancer …, 2021 - Elsevier
Abstract Knowledge of the underpinnings of cancer initiation, progression and metastasis
has increased exponentially in recent years. Advanced “omics” coupled with machine …