The relationship between genome structure and function

AM Oudelaar, DR Higgs - Nature Reviews Genetics, 2021 - nature.com
Precise patterns of gene expression in metazoans are controlled by three classes of
regulatory elements: promoters, enhancers and boundary elements. During differentiation …

Computational methods for analysing multiscale 3D genome organization

Y Zhang, L Boninsegna, M Yang, T Misteli… - Nature Reviews …, 2024 - nature.com
Recent progress in whole-genome mapping and imaging technologies has enabled the
characterization of the spatial organization and folding of the genome in the nucleus. In …

Genome organization controls transcriptional dynamics during development

PJ Batut, XY Bing, Z Sisco, J Raimundo, M Levo… - Science, 2022 - science.org
Past studies offer contradictory claims for the role of genome organization in the regulation
of gene activity. Here, we show through high-resolution chromosome conformation analysis …

EagleC: A deep-learning framework for detecting a full range of structural variations from bulk and single-cell contact maps

X Wang, Y Luan, F Yue - Science Advances, 2022 - science.org
The Hi-C technique has been shown to be a promising method to detect structural variations
(SVs) in human genomes. However, algorithms that can use Hi-C data for a full-range SV …

Visualizing DNA folding and RNA in embryos at single-cell resolution

LJ Mateo, SE Murphy, A Hafner, IS Cinquini, CA Walker… - Nature, 2019 - nature.com
The establishment of cell types during development requires precise interactions between
genes and distal regulatory sequences. We have a limited understanding of how these …

Insights into epigenetic patterns in mammalian early embryos

R Xu, C Li, X Liu, S Gao - Protein & cell, 2021 - academic.oup.com
Mammalian fertilization begins with the fusion of two specialized gametes, followed by major
epigenetic remodeling leading to the formation of a totipotent embryo. During the …

Genome-wide detection of enhancer-hijacking events from chromatin interaction data in rearranged genomes

X Wang, J Xu, B Zhang, Y Hou, F Song, H Lyu, F Yue - Nature methods, 2021 - nature.com
Recent efforts have shown that structural variations (SVs) can disrupt three-dimensional
genome organization and induce enhancer hijacking, yet no computational tools exist to …

[HTML][HTML] Independence of chromatin conformation and gene regulation during Drosophila dorsoventral patterning

E Ing-Simmons, R Vaid, XY Bing, M Levine… - Nature …, 2021 - nature.com
The relationship between chromatin organization and gene regulation remains unclear.
While disruption of chromatin domains and domain boundaries can lead to misexpression of …

Non-coding deletions identify Maenli lncRNA as a limb-specific En1 regulator

L Allou, S Balzano, A Magg, M Quinodoz… - Nature, 2021 - nature.com
Long non-coding RNAs (lncRNAs) can be important components in gene-regulatory
networks, but the exact nature and extent of their involvement in human Mendelian disease …

[HTML][HTML] The little skate genome and the evolutionary emergence of wing-like fins

F Marlétaz, E de la Calle-Mustienes, RD Acemel… - Nature, 2023 - nature.com
Skates are cartilaginous fish whose body plan features enlarged wing-like pectoral fins,
enabling them to thrive in benthic environments,. However, the molecular underpinnings of …