Ferroptosis, a unique modality of cell death with mechanistic and morphological differences
from other cell death modes, plays a pivotal role in regulating tumorigenesis and offers a …

Type 2 diabetes mellitus (T2DM) is characterized by tissue-specific insulin resistance and
pancreatic β-cell dysfunction, which result from the interplay of local abnormalities within …

Nonalcoholic fatty liver disease (NAFLD) encompasses a disease continuum from simple
steatosis to nonalcoholic steatohepatitis (NASH). However, there are currently no approved …

The diversity and dynamics of proteins play essential roles in maintaining the basic
constructions and functions of cells. The abundance of functional proteins is regulated by the …

Posttranslational modifications increase the complexity and functional diversity of proteins in
response to complex external stimuli and internal changes. Among these, protein lipidations …

Histones undergo a plethora of post-translational modifications (PTMs) that regulate
nucleosome and chromatin dynamics and thus dictate cell fate. Several evidences suggest …

Post-translational modification (PTM) has a significant impact on cellular signaling and
function regulation. In pancreatic β cells, PTMs are involved in insulin secretion, cell …

Aging in humans is associated with abdominal distribution and remodeling of body fat and a
parallel gradual increase in the prevalence of metabolic diseases such as obesity, type 2 …

Obesity entails metabolic alterations across multiple organs, highlighting the role of inter-
organ communication in its pathogenesis. Extracellular vesicles (EVs) are communication …

Gasdermins (GSDMs) serve as pivotal executors of pyroptosis and play crucial roles in host
defence, cytokine secretion, innate immunity, and cancer. However, excessive or …