Islets of Langerhans are islands of endocrine cells scattered throughout the pancreas. A
number of new studies have pointed to the potential for conversion of non-β islet cells in to …

Islet dysfunction—characterized by a combination of defective insulin secretion,
inappropriately high glucagon secretion and reduced β-cell mass—has a central role in the …

Background: Sleep loss can modify energy intake and expenditure. Objective: To determine
whether sleep restriction attenuates the effect of a reduced-calorie diet on excess adiposity …

Ghrelin is a gastric peptide hormone that stimulates weight gain in vertebrates. The
biological activities of ghrelin require octanoylation of the peptide on Ser3, an unusual …

G protein–coupled receptors (GPCRs) continue to be important discovery targets for the
treatment of type 2 diabetes mellitus (T2DM). Many GPCRs are directly involved in the …

During the establishment of pregnancy, the ovarian-derived hormones progesterone and
oestradiol regulate remodelling of the endometrium to promote an environment that is able …

Background Accumulating data support the atheroprotective role of the novel adipokines,
apelin and ghrelin. The aim of the present randomized study was to investigate the effects of …

Background Besides being a risk factor for multiple metabolic disorders, obesity could affect
female reproduction. While increased adiposity is associated with hormonal changes that …

Background The aim of this study was to evaluate the possible role of sleeve gastrectomy
(SG) per se in the reversibility of diabetes. Methods Insulin secretion and peripheral insulin …

The existence of constitutive activity for G protein-coupled receptors (GPCRs) was first
described in 1980s. In 1991, the first naturally occurring constitutively active mutations in …