Context-specific regulation of extracellular vesicle biogenesis and cargo selection

AC Dixson, TR Dawson, D Di Vizio… - … Reviews Molecular Cell …, 2023 - nature.com
To coordinate, adapt and respond to biological signals, cells convey specific messages to
other cells. An important aspect of cell–cell communication involves secretion of molecules …

[HTML][HTML] Regulation of phospholipid distribution in the lipid bilayer by flippases and scramblases

T Sakuragi, S Nagata - Nature Reviews Molecular Cell Biology, 2023 - nature.com
Cellular membranes function as permeability barriers that separate cells from the external
environment or partition cells into distinct compartments. These membranes are lipid …

[HTML][HTML] Drugs that inhibit TMEM16 proteins block SARS-CoV-2 spike-induced syncytia

L Braga, H Ali, I Secco, E Chiavacci, G Neves… - Nature, 2021 - nature.com
COVID-19 is a disease with unique characteristics that include lung thrombosis, frequent
diarrhoea, abnormal activation of the inflammatory response and rapid deterioration of lung …

Apoptosis, pyroptosis, and necroptosis—Oh my! The many ways a cell can die

N Ketelut-Carneiro, KA Fitzgerald - Journal of molecular biology, 2022 - Elsevier
Cell death is an essential process in all living organisms and occurs through different
mechanisms. The three main types of programmed cell death are apoptosis, pyroptosis, and …

The clearance of dead cells by efferocytosis

E Boada-Romero, J Martinez, BL Heckmann… - … reviews Molecular cell …, 2020 - nature.com
Multiple modes of cell death have been identified, each with a unique function and each
induced in a setting-dependent manner. As billions of cells die during mammalian …

Interplay between platelets and coagulation

Y Sang, M Roest, B de Laat, PG de Groot, D Huskens - Blood reviews, 2021 - Elsevier
Haemostasis stops bleeding at the site of vascular injury and maintains the integrity of blood
vessels through clot formation. This regulated physiological process consists of complex …

Understanding the diversity of membrane lipid composition

T Harayama, H Riezman - Nature reviews Molecular cell biology, 2018 - nature.com
Cellular membranes are formed from a chemically diverse set of lipids present in various
amounts and proportions. A high lipid diversity is universal in eukaryotes and is seen from …

Neuronal cell death

M Fricker, AM Tolkovsky, V Borutaite… - Physiological …, 2018 - journals.physiology.org
Neuronal cell death occurs extensively during development and pathology, where it is
especially important because of the limited capacity of adult neurons to proliferate or be …

Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia

N Scott‐Hewitt, F Perrucci, R Morini, M Erreni… - The EMBO …, 2020 - embopress.org
Neuronal circuit assembly requires the fine balance between synapse formation and
elimination. Microglia, through the elimination of supernumerary synapses, have an …

How macrophages deal with death

G Lemke - Nature Reviews Immunology, 2019 - nature.com
Tissue macrophages rapidly recognize and engulf apoptotic cells. These events require the
display of so-called eat-me signals on the apoptotic cell surface, the most fundamental of …