Effects of alpha-fetoprotein on the occurrence and progression of hepatocellular carcinoma

Y Zheng, M Zhu, M Li - Journal of cancer research and clinical oncology, 2020 - Springer
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world.
Alpha-fetoprotein (AFP) is considered as a diagnostic and prognostic tumorous marker for …

Hepatoid adenocarcinoma—Clinicopathological features and molecular characteristics

M Li, YX Mei, JH Wen, YR Jiao, QR Pan, XX Kong, J Li - Cancer Letters, 2023 - Elsevier
Hepatoid adenocarcinoma (HAC) is a rare, malignant, extrahepatic tumor with histologic
features similar to those of hepatocellular carcinoma. HAC is most often associated with …

Alpha-fetoprotein inhibits autophagy to promote malignant behaviour in hepatocellular carcinoma cells by activating PI3K/AKT/mTOR signalling

S Wang, M Zhu, Q Wang, Y Hou, L Li, H Weng… - Cell death & …, 2018 - nature.com
Alpha-fetoprotein (AFP) has been recognized as a key regulator of cell proliferation in
hepatocellular carcinoma (HCC). However, whether AFP functions in cancer cell autophagy …

Alpha fetoprotein plays a critical role in promoting metastasis of hepatocellular carcinoma cells

Y Lu, M Zhu, W Li, B Lin, X Dong… - Journal of Cellular …, 2016 - Wiley Online Library
A high level of serum alpha fetoprotein (AFP) is positively associated with human
hepatocellular carcinoma (HCC) carcinogenesis and metastasis; however, the function of …

HBx drives alpha fetoprotein expression to promote initiation of liver cancer stem cells through activating PI3K/AKT signal pathway

M Zhu, W Li, Y Lu, X Dong, B Lin… - … Journal of Cancer, 2017 - Wiley Online Library
Hepatitis B virus (HBV)‐X protein (HBx) plays critical role in inducing the malignant
transformation of liver cells. Alpha fetoprotein (AFP) expression is closely related to …

AFP-Inhibiting fragments for drug delivery: the promise and challenges of targeting therapeutics to cancers

B Lin, X Dong, Q Wang, W Li, M Zhu… - Frontiers in Cell and …, 2021 - frontiersin.org
Alpha fetoprotein (AFP) plays a key role in stimulating the growth, metastasis and drug
resistance of hepatocellular carcinoma (HCC). AFP is an important target molecule in the …

The emerging influences of alpha-fetoprotein in the tumorigenesis and progression of hepatocellular carcinoma

Y Xu, Q Guo, L Wei - Cancers, 2021 - mdpi.com
Simple Summary Hepatocellular carcinoma is characterized by aggressive invasion, rapid
progress and poor prognosis. Since hepatocellular carcinoma is a highly heterogeneous …

[HTML][HTML] Hepatitis B virus X protein induces expression of alpha-fetoprotein and activates PI3K/mTOR signaling pathway in liver cells

M Zhu, J Guo, W Li, Y Lu, S Fu, X Xie, H Xia, X Dong… - Oncotarget, 2015 - ncbi.nlm.nih.gov
The hepatitis B virus (HBV)-X protein (HBx) induces malignant transformation of liver cells,
and elevated expression of alpha-fetoprotein (AFP) is a significant biomarker of …

AFP deletion leads to anti-tumorigenic but pro-metastatic roles in liver cancers with concomitant CTNNB1 mutations

Y Xu, X Zhang, R Zhang, Y Sun, J Liu, C Luo, J Yang… - Cancer Letters, 2023 - Elsevier
HCC remains one of the most prevalent and deadliest cancers. Serum AFP level is a
biomarker for clinical diagnosis of HCC, instead the contribution of AFP to HCC …

[HTML][HTML] Alpha-fetoprotein still is a valuable diagnostic and prognosis predicting biomarker in hepatitis B virus infection-related hepatocellular carcinoma

M Yao, J Zhao, F Lu - Oncotarget, 2016 - ncbi.nlm.nih.gov
Use of serum alpha-fetoprotein (AFP) in clinical practices has been challenged in recent
years, due to the lack of specificity and sensitivity. Here we conducted a retrospective study …