Cytoadhesion of P lasmodium falciparum‐infected erythrocytes to host microvasculature is a
key virulence determinant. Parasite binding is mediated by a large family of clonally variant …

Plasmodium falciparum causes the most severe form of malaria and is responsible for
essentially all malaria-related deaths. The accumulation in various tissues of erythrocytes …

Sequestration of Plasmodium falciparum-infected erythrocytes in host blood vessels is a key
triggering event in the pathogenesis of severe childhood malaria, which is responsible for …

Cerebral malaria is the most deadly manifestation of infection with Plasmodium falciparum.
The pathology of cerebral malaria is characterized by the accumulation of infected …

Brain swelling is a major predictor of mortality in pediatric cerebral malaria (CM). However,
the mechanisms leading to swelling remain poorly defined. Here, we combined …

ABSTRACT Intercellular adhesion molecule 1 (ICAM-1) and the endothelial protein C
receptor (EPCR) are candidate receptors for the deadly complication cerebral malaria …

The interplay between cellular and molecular determinants that lead to severe malaria in
adults is unexplored. Here, we analyzed parasite virulence factors in an infected adult …

The Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family has a key role
in parasite survival, transmission, and virulence. PfEMP1 are exported to the erythrocyte …

Severe malaria due to Plasmodium falciparum infection causes nearly half a million deaths
per year. The different symptomatology and disease manifestations among patients have …

Most severe Plasmodium falciparum infections are experienced by young children. Severe
symptoms are precipitated by vascular sequestration of parasites expressing a particular …