Scrambling the genome in cancer: causes and consequences of complex chromosome rearrangements
K Krupina, A Goginashvili, DW Cleveland - Nature Reviews Genetics, 2024 - nature.com
Complex chromosome rearrangements, known as chromoanagenesis, are widespread in
cancer. Based on large-scale DNA sequencing of human tumours, the most frequent type of …
cancer. Based on large-scale DNA sequencing of human tumours, the most frequent type of …
On-site airborne pathogen detection for infection risk mitigation
Human-infecting pathogens that transmit through the air pose a significant threat to public
health. As a prominent instance, the severe acute respiratory syndrome coronavirus 2 …
health. As a prominent instance, the severe acute respiratory syndrome coronavirus 2 …
Chromatin bridges: stochastic breakage or regulated resolution?
H Jiang, YW Chan - Trends in Genetics, 2023 - cell.com
Genetic material is organized in the form of chromosomes, which need to be segregated
accurately into two daughter cells in each cell cycle. However, chromosome fusion or the …
accurately into two daughter cells in each cell cycle. However, chromosome fusion or the …
A benzochalcone derivative synchronously induces apoptosis and ferroptosis in pancreatic cancer cells
Background Pancreatic cancer is a highly aggressive and lethal disease with limited
treatment options. In this study, we investigated the potential therapeutic effects of …
treatment options. In this study, we investigated the potential therapeutic effects of …
The Calpain-7 protease functions together with the ESCRT-III protein IST1 within the midbody to regulate the timing and completion of abscission
EL Paine, JJ Skalicky, FG Whitby, DR Mackay… - Elife, 2023 - elifesciences.org
Abstract The Endosomal Sorting Complexes Required for Transport (ESCRT) machinery
mediates the membrane fission step that completes cytokinetic abscission and separates …
mediates the membrane fission step that completes cytokinetic abscission and separates …
cGAS: action in the nucleus
Y Lu, M Zhao, L Chen, Y Wang, T Liu, H Liu - Frontiers in Immunology, 2024 - frontiersin.org
As a canonical cytoplasmic DNA sensor, cyclic GMP-AMP synthase (cGAS) plays a key role
in innate immunity. In recent years, a growing number of studies have shown that cGAS can …
in innate immunity. In recent years, a growing number of studies have shown that cGAS can …
The cytosolic DNA‐sensing cGAS–STING pathway in neurodegenerative diseases
X Guo, L Yang, J Wang, Y Wu, Y Li, L Du… - CNS Neuroscience …, 2024 - Wiley Online Library
Background With the widespread prevalence of neurodegenerative diseases (NDs) and
high rates of mortality and disability, it is imminent to find accurate targets for intervention …
high rates of mortality and disability, it is imminent to find accurate targets for intervention …
Pauperization of Emerin from nuclear envelope during chromatin bridge resolution drives prostate cancer cell migration and invasiveness
P Nastaly, M Popeda, K Kowalski, T Wenta… - bioRxiv, 2023 - biorxiv.org
Micronuclei (MN) can arise from many causes, including the breakage of aberrant
cytokinetic chromatin bridge. The frequent observation of MN in tumors raises the specter …
cytokinetic chromatin bridge. The frequent observation of MN in tumors raises the specter …