The thick waxy coat of mycobacteria, a protective layer against antibiotics and the host's immune system
SM Batt, DE Minnikin, GS Besra - Biochemical Journal, 2020 - portlandpress.com
Tuberculosis, caused by the pathogenic bacterium Mycobacterium tuberculosis (Mtb), is the
leading cause of death from an infectious disease, with a mortality rate of over a million …
leading cause of death from an infectious disease, with a mortality rate of over a million …
How sisters grow apart: mycobacterial growth and division
KJ Kieser, EJ Rubin - Nature Reviews Microbiology, 2014 - nature.com
Mycobacterium tuberculosis, which is the aetiological agent of tuberculosis, owes much of its
success as a pathogen to its unique cell wall and unusual mechanism of growth, which …
success as a pathogen to its unique cell wall and unusual mechanism of growth, which …
pLogo: a probabilistic approach to visualizing sequence motifs
JP O'shea, MF Chou, SA Quader, JK Ryan… - Nature …, 2013 - nature.com
Methods for visualizing protein or nucleic acid motifs have traditionally relied upon residue
frequencies to graphically scale character heights. We describe the pLogo, a motif …
frequencies to graphically scale character heights. We describe the pLogo, a motif …
Eukaryote-like serine/threonine kinases and phosphatases in bacteria
SFF Pereira, L Goss, J Dworkin - Microbiology and Molecular …, 2011 - Am Soc Microbiol
Genomic studies have revealed the presence of Ser/Thr kinases and phosphatases in many
bacterial species, although their physiological roles have largely been unclear. Here we …
bacterial species, although their physiological roles have largely been unclear. Here we …
Regulation of bacterial cell wall growth
During growth and propagation, a bacterial cell enlarges and subsequently divides its
peptidoglycan (PG) sacculus, a continuous mesh‐like layer that encases the cell membrane …
peptidoglycan (PG) sacculus, a continuous mesh‐like layer that encases the cell membrane …
Beyond gene expression: the impact of protein post-translational modifications in bacteria
JA Cain, N Solis, SJ Cordwell - Journal of proteomics, 2014 - Elsevier
The post-translational modification (PTM) of proteins plays a critical role in the regulation of
a broad range of cellular processes in eukaryotes. Yet their role in governing similar systems …
a broad range of cellular processes in eukaryotes. Yet their role in governing similar systems …
Cross‐talk between phosphorylation and lysine acetylation in a genome‐reduced bacterium
V van Noort, J Seebacher, S Bader… - Molecular systems …, 2012 - embopress.org
Protein post‐translational modifications (PTMs) represent important regulatory states that
when combined have been hypothesized to act as molecular codes and to generate a …
when combined have been hypothesized to act as molecular codes and to generate a …
Proteome-wide lysine acetylation profiling of the human pathogen Mycobacterium tuberculosis
L Xie, X Wang, J Zeng, M Zhou, X Duan, Q Li… - The international journal …, 2015 - Elsevier
N ɛ-Acetylation of lysine residues represents a pivotal post-translational modification used
by both eukaryotes and prokaryotes to modulate diverse biological processes …
by both eukaryotes and prokaryotes to modulate diverse biological processes …
[HTML][HTML] MmpL Proteins in Physiology and Pathogenesis of M. tuberculosis
G Melly, GE Purdy - Microorganisms, 2019 - mdpi.com
Mycobacterium tuberculosis (Mtb) remains an important human pathogen. The Mtb cell
envelope is a critical bacterial structure that contributes to virulence and pathogenicity …
envelope is a critical bacterial structure that contributes to virulence and pathogenicity …
A phosphorylated pseudokinase complex controls cell wall synthesis in mycobacteria
CL Gee, KG Papavinasasundaram, SR Blair… - Science …, 2012 - science.org
Prokaryotic cell wall biosynthesis is coordinated with cell growth and division, but the
mechanisms regulating this dynamic process remain obscure. Here, we describe a …
mechanisms regulating this dynamic process remain obscure. Here, we describe a …