New insights into the pivotal role of the amygdala in inflammation-related depression and anxiety disorder
P Hu, Y Lu, BX Pan, WH Zhang - International Journal of Molecular …, 2022 - mdpi.com
Depression and anxiety disorders are the two most prevalent psychiatric diseases that affect
hundreds of millions of individuals worldwide. Understanding the etiology and related …
hundreds of millions of individuals worldwide. Understanding the etiology and related …
Possible antidepressant mechanisms of omega-3 polyunsaturated fatty acids acting on the central nervous system
L Zhou, JY Xiong, YQ Chai, L Huang, ZY Tang… - Frontiers in …, 2022 - frontiersin.org
Omega-3 polyunsaturated fatty acids (PUFAs) can play important roles in maintaining
mental health and resistance to stress, and omega-3 PUFAs supplementation can display …
mental health and resistance to stress, and omega-3 PUFAs supplementation can display …
Recent progress in research on Momordica charantia polysaccharides: extraction, purification, structural characteristics and bioactivities
K Zhan, X Ji, L Luo - Chemical and Biological Technologies in Agriculture, 2023 - Springer
Abstract Momordica charantia (M. charantia), as a common edible vegetable and herb, is
mainly distributed in tropical and subtropical regions of the world. M. charantia …
mainly distributed in tropical and subtropical regions of the world. M. charantia …
A network pharmacology approach to predict potential targets and mechanisms of “Ramulus Cinnamomi (cassiae) – Paeonia lactiflora” herb pair in the treatment of …
HT Pan, ZQ Xi, XQ Wei, K Wang - Annals of Medicine, 2022 - Taylor & Francis
Abstract Background Traditional Chinese medicine (TCM) prescriptions have multiple
bioactive properties.“Gui Zhi–Shao Yao” herb pair is widely used to treat chronic pain (CP) …
bioactive properties.“Gui Zhi–Shao Yao” herb pair is widely used to treat chronic pain (CP) …
proBDNF expression induces apoptosis and inhibits synaptic regeneration by regulating the RhoA-JNK pathway in an in vitro post-stroke depression model
B Yang, L Wang, Y Nie, W Wei, W Xiong - Translational psychiatry, 2021 - nature.com
Brain-derived neurotrophic factor (BDNF) plays an important role in the pathophysiology of
post-stroke depression (PSD). However, the precise function and potential mechanism of …
post-stroke depression (PSD). However, the precise function and potential mechanism of …
Suppression of LPS-induced inflammation and cell migration by azelastine through inhibition of JNK/NF-κB pathway in BV2 microglial cells
The c-Jun N-terminal kinases (JNKs) are implicated in many neuropathological conditions,
including neurodegenerative diseases. To explore potential JNK3 inhibitors from the US …
including neurodegenerative diseases. To explore potential JNK3 inhibitors from the US …
Prevotella histicola Mitigated Estrogen Deficiency-Induced Depression via Gut Microbiota-Dependent Modulation of Inflammation in Ovariectomized Mice
F Huang, X Liu, S Xu, S Hu, S Wang, D Shi… - Frontiers in …, 2022 - frontiersin.org
Background Estrogen deficiency-induced depression is closely associated with an
imbalance in intestinal microbiota and inflammation. Prevotella histicola (P. histicola), an …
imbalance in intestinal microbiota and inflammation. Prevotella histicola (P. histicola), an …
Analysis of differentially expressed genes in the dentate gyrus and anterior cingulate cortex in a mouse model of depression
Y Wei, K Qi, Y Yu, W Lu, W Xu… - BioMed Research …, 2021 - Wiley Online Library
Major depressive disorder (MDD) is a prevalent, chronic, and relapse‐prone psychiatric
disease. However, the intermediate molecules resulting from stress and neurological …
disease. However, the intermediate molecules resulting from stress and neurological …
GR/NF-κB signaling pathway regulates hippocampal inflammatory responses in diabetic rats with chronic unpredictable mild stress
ZR Li, YS Han, Z Liu, HQ Zhao, J Liu, H Yang… - European journal of …, 2021 - Elsevier
Clinical studies have shown that diabetes can present with underlying depression, and a
combination of the two can lead to emotional, memory and cognitive disorders, closely …
combination of the two can lead to emotional, memory and cognitive disorders, closely …
Jnk1 and downstream signalling hubs regulate anxiety-like behaviours in a zebrafish larvae phenotypic screen
Y Hong, C Sourander, B Hackl, JS Patton, J John… - Scientific Reports, 2024 - nature.com
Current treatments for anxiety and depression show limited efficacy in many patients,
indicating the need for further research into the underlying mechanisms. JNK1 has been …
indicating the need for further research into the underlying mechanisms. JNK1 has been …