Molecular circuits shared by placental and cancer cells, and their implications in the proliferative, invasive and migratory capacities of trophoblasts

C Ferretti, L Bruni, V Dangles-Marie… - Human reproduction …, 2007 - academic.oup.com
Trophoblast research over the past decades has underlined the striking similarities between
the proliferative, migratory and invasive properties of placental cells and those of cancer …

The IGF axis and placental function: a mini review

K Forbes, M Westwood - Hormone Research in Paediatrics, 2008 - karger.com
It is well known that the insulin-like growth factor (IGF) axis is an important regulator of foetal
growth and in recent years, it has been suggested that the ligands IGF-I and IGF-II may, in …

[PDF][PDF] DPP-4 inhibitors improve cognition and brain mitochondrial function of insulin-resistant rats

H Pintana, N Apaijai, N Chattipakorn… - J Endocrinol, 2013 - researchgate.net
Recent evidence has demonstrated that insulin resistance is related to the development of
type 2 diabetes mellitus. Our previous study found that high-fat diet (HFD) consumption …

The regulation of trophoblast differentiation by oxygen in the first trimester of pregnancy

JL James, PR Stone, LW Chamley - Human reproduction update, 2006 - academic.oup.com
In the first trimester of human pregnancy villous cytotrophoblasts are able to differentiate to
form either the overlying syncytiotrophoblast layer or, in anchoring villi, extravillous …

Insulin-like growth factor I and II regulate the life cycle of trophoblast in the developing human placenta

K Forbes, M Westwood, PN Baker… - American Journal of …, 2008 - journals.physiology.org
The main disorders of human pregnancy are rooted in defective placentation. Normal
placental development depends on proliferation, differentiation, and fusion of …

Signalling pathways regulating the invasive differentiation of human trophoblasts: a review

J Pollheimer, M Knöfler - Placenta, 2005 - Elsevier
The invasive differentiation pathway of trophoblasts is an indispensable physiological
process of early human placental development. Formation of anchoring villi, proliferation of …

ERK1/2 and p38 regulate trophoblasts differentiation in human term placenta

G Daoud, M Amyot, E Rassart, A Masse… - The Journal of …, 2005 - Wiley Online Library
Mitogen‐activated protein kinases (MAPKs) control many cellular events from complex
programmes, such as embryogenesis, cell differentiation and proliferation, and cell death, to …

Involvement of galectin-1 in reproduction: past, present and future

G Barrientos, N Freitag… - Human reproduction …, 2014 - academic.oup.com
BACKGROUND After recognition of its pivotal contribution to fetomaternal tolerance, the
study of galectin-1 (gal-1) functions in the context of pregnancy became an attractive topic in …

The expression of CXCR4/CXCL12 in first-trimester human trophoblast cells

X Wu, DJ Li, MM Yuan, Y Zhu… - Biology of …, 2004 - academic.oup.com
Chemokines and chemokine receptors have been implicated as pivotal players in many
physiological and pathological situations, but little is known about the expression and …

Cannabinoids and the placenta: Receptors, signaling and outcomes

ACE Rokeby, BV Natale, DRC Natale - Placenta, 2023 - Elsevier
Cannabis use during pregnancy is increasing. The improvement of pregnancy-related
symptoms including morning sickness and management of mood and stress are among the …