Rationale Neurosteroids are steroids synthesized within the brain with rapid effects on
neuronal excitability. Allopregnanolone, allotetrahydrodeoxycorticosterone, and …

The neuroactive steroid allopregnanolone (ALLO) is an endogenous positive allosteric
modulator of GABA type A receptor (GABA AR), and the down-regulation of its biosynthesis …

Most antianxiety drugs (anxiolytics) work by modulating neurotransmitters in the brain.
Benzodiazepines are fast and effective anxiolytic drugs; however, their long-term use is …

In the past decades considerable evidence has emerged that so-called neuroactive steroids
do not only act as transcriptional factors in the regulation of gene expression but may also …

BACKGROUND: A proportion of subjects with symptoms of posttraumatic stress disorder
(PTSD) are unresponsive to specialized psychotherapy, but a biological basis for this has …

Recently, the translocator protein (18 kDa)(TSPO), previously called peripheral
benzodiazepine receptor (PBR) and both the starting point and an important rate-limiting …

The pharmacological action of selective serotonin reuptake inhibitor antidepressants may
include a normalization of the decreased brain levels of the brain-derived neurotrophic …

Pharmacological studies have implicated the translocator protein (TSPO) in the regulation of
complex behaviors including anxiety and depression, effects thought to be mediated by …

Certain steroid hormone metabolites that have activity as modulators of GABAA receptors
but lack conventional hormonal effects—including allopregnanolone and …

Introduction: The treatment of anxiety disorders is still a challenge; novel pharmacological
approaches that combine rapid anxiolytic efficacy with fewer side effects are needed. A …