[HTML][HTML] The regulation of bone metabolism and disorders by Wnt signaling

K Maeda, Y Kobayashi, M Koide, S Uehara… - International journal of …, 2019 - mdpi.com
Wnt, a secreted glycoprotein, has an approximate molecular weight of 40 kDa, and it is a
cytokine involved in various biological phenomena including ontogeny, morphogenesis …

WNT signaling in cardiac and vascular disease

S Foulquier, EP Daskalopoulos, G Lluri… - Pharmacological …, 2018 - ASPET
WNT signaling is an elaborate and complex collection of signal transduction pathways
mediated by multiple signaling molecules. WNT signaling is critically important for …

The role of the wnt/β-catenin signaling pathway in formation and maintenance of bone and teeth

P Duan, LF Bonewald - The international journal of biochemistry & cell …, 2016 - Elsevier
The Wnt signaling pathway is known as one of the important molecular cascades that
regulate cell fate throughout lifespan. The Wnt signaling pathway is further separated into …

[HTML][HTML] Epigenetic plasticity drives adipogenic and osteogenic differentiation of marrow-derived mesenchymal stem cells

MB Meyer, NA Benkusky, B Sen, J Rubin… - Journal of Biological …, 2016 - ASBMB
Terminal differentiation of multipotent stem cells is achieved through a coordinated cascade
of activated transcription factors and epigenetic modifications that drive gene transcription …

[HTML][HTML] Progress of wnt signaling pathway in osteoporosis

Y Gao, N Chen, Z Fu, Q Zhang - Biomolecules, 2023 - mdpi.com
Osteoporosis, one of the serious health diseases, involves bone mass loss, bone density
diminishing, and degeneration of bone microstructure, which is accompanied by a tendency …

Novel mechanisms of exosome-mediated phagocytosis of dead cells in injured heart

M Patil, S Saheera, PK Dubey, A Kahn-Krell… - Circulation …, 2021 - Am Heart Assoc
Rationale: After myocardial ischemic injury, improper phagocytic clearance of dying cardiac
cells and the ensuing lack of inflammation resolution results in adverse cardiac remodeling …

[HTML][HTML] Deciphering the relevance of bone ECM signaling

N Alcorta-Sevillano, I Macías, A Infante, CI Rodríguez - Cells, 2020 - mdpi.com
Bone mineral density, a bone matrix parameter frequently used to predict fracture risk, is not
the only one to affect bone fragility. Other factors, including the extracellular matrix (ECM) …

The role of the microenvironment in controlling the fate of bioprinted stem cells

LN West-Livingston, J Park, SJ Lee, A Atala… - Chemical …, 2020 - ACS Publications
The field of tissue engineering and regenerative medicine has made numerous advances in
recent years in the arena of fabricating multifunctional, three-dimensional (3D) tissue …

Extracellular matrix stiffness and Wnt/β-catenin signaling in physiology and disease

P Astudillo - Biochemical Society Transactions, 2020 - portlandpress.com
The Wnt/β-catenin signaling pathway plays fundamental roles during development, stem cell
differentiation, and homeostasis, and its abnormal activation can lead to diseases. In recent …

Down-regulated lncRNA MEG3 promotes osteogenic differentiation of human dental follicle stem cells by epigenetically regulating Wnt pathway

L Deng, H Hong, X Zhang, D Chen, Z Chen… - Biochemical and …, 2018 - Elsevier
Our previous long noncoding RNA (lncRNA) microarray results showed that lncRNA MEG3
(maternally expressed 3) was significantly downregulated in human dental follicle cells than …