Physiological Approach to Assessment of Acid–Base Disturbances | NEJM Skip to main content
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Diabetic ketoacidosis (DKA) is a form of a hyperglycemic emergency mainly characterized
by the triad of hyperglycemia, ketosis, and anion gap metabolic acidosis. DKA may be the …

Objectives: The Stewart approach states that pH is primarily determined by Pco 2, strong ion
difference (SID), and nonvolatile weak acids. This method might identify severe metabolic …

Background The relationship between albumin corrected anion gap (ACAG) and in-hospital
mortality of intensive care sepsis patients is currently inconclusive. Methods The baseline …

Acid–base abnormalities are common in critically ill patients. Our ability to describe acid–
base disorders must be precise. Small differences in corrections for anion gap, different …

Introduction Acute metabolic acidosis of non-renal origin is usually a result of either lactic or
ketoacidosis, both of which are associated with a high anion gap. There is increasing …

We aimed to investigate the association between the plasma anion gap (AG) and in-hospital
mortality among patients with acute ischemic stroke (AIS). In total, 1236 AIS patients were …

Background: Conflicting data exist as to what extent hypoalbuminemia reduces the anion
gap; estimates range from 1.5 to 2.5 mM per g/dL decrease in serum albumin. Methods: We …

Acid–base and electrolyte analysis in critically ill patient... : Current Opinion in Critical Care
Acid–base and electrolyte analysis in critically ill patients: are we ready for the new millennium …

Albumin is produced by the liver. Among its many functions are its ability to maintain
intravascular oncotic pressure, facilitate transportation of substances, and act as a free …