Evidence implicates hyperglycemia-derived oxygen free radicals as mediators of diabetic
complications. However, intervention studies with classic antioxidants, such as vitamin E …

The vascular endothelium synthesises the vasodilator and anti-aggregatory mediator nitric
oxide (NO) from L-arginine. This action is catalysed by the action of NO synthases, of which …

Nitric oxide (NO) is one of the most important molecules released by endothelial cells, and
its antiatherogenic properties support cardiovascular homeostasis. Diminished NO …

Lowering plasma low density lipoprotein-cholesterol (LDL-C), blood pressure,
homocysteine, and preventing platelet aggregation using a combination of a statin, three …

Low-density lipoprotein (LDL) cholesterol is an established risk factor for coronary heart
disease (CHD). In the presence of oxidative stress LDL particles can become oxidized to …

Despite all the advances of modern medicine, atherosclerosis continues to be one of the
most important medical and social problems. Atherosclerosis is the cause of several …

Increasing evidence in both experimental and clinical studies suggests that there is a close
link between hyperglycemia, oxidative stress and diabetic complications. High blood …

One of the effective managements of diabetes mellitus, in particular, noninsulin-dependent
diabetes mellitus, is to retard the absorption of glucose by inhibition of carbohydrate …

Background—HMG-CoA reductase inhibitors (statins) have been shown to beneficially affect
outcomes in chronic heart failure (CHF). We hypothesized that statins exert effects on …

In recent years, a growing interest has arisen regarding the possible relationship between
adverse pregnancy outcomes (APOs) and inadequate maternal hemodynamic adaptations …