Over 150 million people, including many children, live at high altitude (> 2500 m) with the
majority residing in Asia and South America. With increases in elevation, the partial pressure …

Patients with congenital heart disease are surviving further into adulthood and want to
participate in multiple activities. This includes exposure to high altitude by air travel or …

Patients with Fontan circulation are particularly dependent on low pulmonary vascular
resistance because their lungs are passively perfused. Hypoxia drives pulmonary …

Purpose For Fontan-palliated patients, altitude exposure is still a part of discussion since the
extent of hypoxic pulmonary vasoconstriction potentially resulting in decreasing cardiac …

Coronary artery disease is one of the main causes of mortality and morbidity among chronic
heart diseases worldwide. Patients reported chronic chest pain as the primary symptom of …

Objective Physical activity at high altitude is expected to pose risks for patients with Fontan
circulation and to impair systemic ventricular function. This study aims to determine the effect …

During the last decades, the number of lowland children exposed to high altitude (HA) has
increased drastically. Several factors may influence the development of illness after acute …

Introduction At cruising altitude, the cabin pressure of passenger aircraft needs to be
adjusted and, therefore, the oxygen content is equivalent to ambient air at 2,500 masl …

Patients with Fontan circulation are particularly dependent on low pulmonary vascular
resistance because their lungs are passively perfused. Hypoxia drives pulmonary …

Patients who have undergone Fontan palliation have reduced exercise tolerance measured
by maximal oxygen consumption (VO2 max). Declining exercise capacity is associated with …