Sequencing pools of individuals—mining genome-wide polymorphism data without big funding
The analysis of polymorphism data is becoming increasingly important as a complementary
tool to classical genetic analyses. Nevertheless, despite plunging sequencing costs …
tool to classical genetic analyses. Nevertheless, despite plunging sequencing costs …
Genome-wide association studies for complex traits: consensus, uncertainty and challenges
The past year has witnessed substantial advances in understanding the genetic basis of
many common phenotypes of biomedical importance. These advances have been the result …
many common phenotypes of biomedical importance. These advances have been the result …
Group testing: an information theory perspective
The group testing problem concerns discovering a small number of defective items within a
large population by performing tests on pools of items. A test is positive if the pool contains …
large population by performing tests on pools of items. A test is positive if the pool contains …
Genome-wide association studies for common diseases and complex traits
JN Hirschhorn, MJ Daly - Nature reviews genetics, 2005 - nature.com
Genetic factors strongly affect susceptibility to common diseases and also influence disease-
related quantitative traits. Identifying the relevant genes has been difficult, in part because …
related quantitative traits. Identifying the relevant genes has been difficult, in part because …
Marker‐assisted selection in plant breeding: From publications to practice
The volume of publications on the development and to a lesser extent the application of
molecular markers in plant breeding has increased dramatically during the last decade …
molecular markers in plant breeding has increased dramatically during the last decade …
Gene–environment-wide association studies: emerging approaches
D Thomas - Nature reviews genetics, 2010 - nature.com
Despite the yield of recent genome-wide association (GWA) studies, the identified variants
explain only a small proportion of the heritability of most complex diseases. This …
explain only a small proportion of the heritability of most complex diseases. This …
SNPs in ecology, evolution and conservation
Over the past two decades, new molecular genetic techniques have had substantial impacts
on the fields of ecology, evolution and conservation. However, our current toolbox of genetic …
on the fields of ecology, evolution and conservation. However, our current toolbox of genetic …
Using next-generation sequencing to isolate mutant genes from forward genetic screens
K Schneeberger - Nature Reviews Genetics, 2014 - nature.com
The long-lasting success of forward genetic screens relies on the simple molecular basis of
the characterized phenotypes, which are typically caused by mutations in single genes …
the characterized phenotypes, which are typically caused by mutations in single genes …
Genome-wide strategies for detecting multiple loci that influence complex diseases
J Marchini, P Donnelly, LR Cardon - Nature genetics, 2005 - nature.com
After nearly 10 years of intense academic and commercial research effort, large genome-
wide association studies for common complex diseases are now imminent. Although these …
wide association studies for common complex diseases are now imminent. Although these …
A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder
AE Baum, N Akula, M Cabanero, I Cardona… - Molecular …, 2008 - nature.com
The genetic basis of bipolar disorder has long been thought to be complex, with the potential
involvement of multiple genes, but methods to analyze populations with respect to this …
involvement of multiple genes, but methods to analyze populations with respect to this …