Family history is a major risk factor for myocardial infarction (MI). However, known gene
variants associated with MI cannot fully explain the genetic component of MI risk. We …

Recent studies have revealed that linkage disequilibrium (LD) patterns vary across the
human genome with some regions of high LD interspersed by regions of low LD. A small …

Objective To identify promising candidate genes linked to interindividual differences in the
efficacy of interferon beta therapy. Recombinant interferon beta therapy is widely used to …

BACKGROUND: Real-time (RT) PCR methods for discovering and genotyping single
nucleotide polymorphisms (SNPs) are becoming increasingly important in various fields of …

Haplotype phase information in diploid organisms provides valuable information on human
evolutionary history and may lead to the development of more efficient strategies to identify …

Large exploratory studies, including candidate-gene–association testing, genomewide
linkage-disequilibrium scans, and array-expression experiments, are becoming increasingly …

With the imminent availability of ultra-high-volume genotyping platforms (on the order of
100,000–1,000,000 genotypes per sample) at a manageable cost, there is growing interest …

ent generations. Regions that potentially harbor a diseasecausing gene are identified by
testing of the cosegregation of the disease with genetic markers that tag specific regions of …

Background ADHD is a common and complex genetic disorder. Genetic risk factors are
expected to be multiple, have small effect sizes when considered individually and to interact …

Matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry
has become one of the most powerful and widely applied technologies for SNP scoring and …