Drugs, their targets and the nature and number of drug targets | Nature Reviews Drug Discovery
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Coagulation abnormalities, ranging from a simple fall in platelet count to full-blown
disseminated intravascular coagulation, are a common occurrence in critically ill patients …

Life-threatening complications from bacterial infections are a major and growing clinical
problem, aggravated by the emergence and spread of antibiotic resistance in bacterial …

PURPOSE: To compare the efficacy, safety, and costs associated with catheter-directed
thrombolysis with urokinase (UK) and the recombinant agents alteplase (tissue plasminogen …

Conversion of fibrinogen into fibrin results in the exposure of cryptic interaction sites and
modulation of various activities. To elucidate the mechanism of this exposure, we tested the …

TNK-tissue plasminogen activator (TNK-t-PA), a bioengineered variant of tissue-type
plasminogen activator (t-PA), has a longer half-life than t-PA because the glycosylation site …

Background Although thrombolytic therapy given by bolus injection seems to be as effective
as infusion over 60–90 min, no single trial has been adequately powered to detect clinically …

Background We noticed substantial residual thrombus on intravascular ultrasound (IVUS) in
many limbs despite restoration of flow after thrombolysis. Since thrombus burden has been …

Estrogen deficiency impairs fracture healing, while estrogen treatment of ovariectomized rats
accelerates fracture healing. To identify genes regulated by estrogen during fracture …

OBJECTIVE To review the literature pertaining to the efficacy of alteplase for restoration of
patency of occluded venous and dialysis catheters in pediatric patients. DATA SOURCES A …