Role of oxidative stress in the pathogenesis of non-alcoholic fatty liver disease: implications for prevention and therapy
JC Arroyave-Ospina, Z Wu, Y Geng, H Moshage - Antioxidants, 2021 - mdpi.com
Oxidative stress (OxS) is considered a major factor in the pathophysiology of inflammatory
chronic liver diseases, including non-alcoholic liver disease (NAFLD). Chronic impairment of …
chronic liver diseases, including non-alcoholic liver disease (NAFLD). Chronic impairment of …
The Keap1‐Nrf2 system: a mediator between oxidative stress and aging
C Yu, JH Xiao - Oxidative Medicine and Cellular Longevity, 2021 - Wiley Online Library
Oxidative stress, a term that describes the imbalance between oxidants and antioxidants,
leads to the disruption of redox signals and causes molecular damage. Increased oxidative …
leads to the disruption of redox signals and causes molecular damage. Increased oxidative …
Dietary flavonoids: Cardioprotective potential with antioxidant effects and their pharmacokinetic, toxicological and therapeutic concerns
Flavonoids comprise a large group of structurally diverse polyphenolic compounds of plant
origin and are abundantly found in human diet such as fruits, vegetables, grains, tea, dairy …
origin and are abundantly found in human diet such as fruits, vegetables, grains, tea, dairy …
An update of Nrf2 activators and inhibitors in cancer prevention/promotion
F Pouremamali, A Pouremamali, M Dadashpour… - Cell Communication and …, 2022 - Springer
Abstract NF-E2-related factor 2 (Nrf2) protein is a basic-region leucine zipper transcription
factor that defends against endogenous or exogenous stressors. By inducing several …
factor that defends against endogenous or exogenous stressors. By inducing several …
Aldo-keto reductases and cancer drug resistance
TM Penning, S Jonnalagadda, PC Trippier… - Pharmacological …, 2021 - ASPET
Human aldo-keto reductases (AKRs) catalyze the NADPH-dependent reduction of carbonyl
groups to alcohols for conjugation reactions to proceed. They are implicated in resistance to …
groups to alcohols for conjugation reactions to proceed. They are implicated in resistance to …
Luteolin Alleviates AflatoxinB1-Induced Apoptosis and Oxidative Stress in the Liver of Mice through Activation of Nrf2 Signaling Pathway
Aflatoxin B1 (AFB1), a threatening mycotoxin, usually provokes oxidative stress and causes
hepatotoxicity in animals and humans. Luteolin (LUTN), well-known as an active …
hepatotoxicity in animals and humans. Luteolin (LUTN), well-known as an active …
Antioxidant and anti-inflammation effects of dietary phytochemicals: The Nrf2/NF-κB signalling pathway and upstream factors of Nrf2
S Wu, X Liao, Z Zhu, R Huang, M Chen, A Huang… - Phytochemistry, 2022 - Elsevier
Oxidative stress (OS) is created by an imbalance between reactive oxygen species and
antioxidant levels. OS promotes inflammation and is associated with many diseases, such …
antioxidant levels. OS promotes inflammation and is associated with many diseases, such …
The potential of flavonoids and flavonoid metabolites in the treatment of neurodegenerative pathology in disorders of cognitive decline
J Melrose - Antioxidants, 2023 - mdpi.com
Flavonoids are a biodiverse family of dietary compounds that have antioxidant, anti-
inflammatory, antiviral, and antibacterial cell protective profiles. They have received …
inflammatory, antiviral, and antibacterial cell protective profiles. They have received …
Standard of care versus new-wave corticosteroids in the treatment of Duchenne muscular dystrophy: Can we do better?
S Kourakis, CA Timpani, DG Campelj, P Hafner… - Orphanet Journal of …, 2021 - Springer
Background Pharmacological corticosteroid therapy is the standard of care in Duchenne
Muscular Dystrophy (DMD) that aims to control symptoms and slow disease progression …
Muscular Dystrophy (DMD) that aims to control symptoms and slow disease progression …
Flavonoids in treatment of chronic kidney disease
Chronic kidney disease (CKD) is a progressive systemic disease, which changes the
function and structure of the kidneys irreversibly over months or years. The final common …
function and structure of the kidneys irreversibly over months or years. The final common …