Unwinding circular RNA's role in inflammatory pulmonary diseases
Circular RNAs (circRNAs) have emerged as pivotal regulators of gene expression and
cellular processes in various physiological and pathological conditions. In recent years …
cellular processes in various physiological and pathological conditions. In recent years …
Role of mammalian target of rapamycin (mTOR) signalling in oncogenesis
The signalling system known as mammalian target of rapamycin (mTOR) is believed to be
required for several biological activities involving cell proliferation. The serine-threonine …
required for several biological activities involving cell proliferation. The serine-threonine …
Protein neddylation and its role in health and diseases
NEDD8 (Neural precursor cell expressed developmentally downregulated protein 8) is an
ubiquitin-like protein that is covalently attached to a lysine residue of a protein substrate …
ubiquitin-like protein that is covalently attached to a lysine residue of a protein substrate …
In-depth metaproteomics analysis of tongue coating for gastric cancer: a multicenter diagnostic research study
J Chen, Y Sun, J Li, M Lyu, L Yuan, J Sun, S Chen… - Microbiome, 2024 - Springer
Background Our previous study revealed marked differences in tongue images between
individuals with gastric cancer and those without gastric cancer. However, the biological …
individuals with gastric cancer and those without gastric cancer. However, the biological …
Hypoxia-induced transcriptional stress is mediated by ROS-induced R-loops
TS Ma, KR Worth, C Maher, N Ng, C Beghè… - Nucleic acids …, 2023 - academic.oup.com
Hypoxia is a common feature of solid tumors and is associated with poor patient prognosis,
therapy resistance and metastasis. Radiobiological hypoxia (< 0.1% O2) is one of the few …
therapy resistance and metastasis. Radiobiological hypoxia (< 0.1% O2) is one of the few …
Noncoding RNA Contribution to Aging and Lifespan
AP Ugalde, D Roiz-Valle… - The Journals of …, 2024 - academic.oup.com
Aging is a multifactorial process characterized by an age-related decline in organismal
fitness. This deterioration is the major risk factor for chronic diseases such as cardiovascular …
fitness. This deterioration is the major risk factor for chronic diseases such as cardiovascular …
Targeting Translation and the Cell Cycle Inversely Affects CTC Metabolism but Not Metastasis
TY Bowley, SD Merkley, IV Lagutina, MC Ortiz, M Lee… - Cancers, 2023 - mdpi.com
Simple Summary This study identifies specific ribosomal proteins that drive MBM and
extracranial metastasis via CTCs. Dual targeting of cellular translation and proliferation …
extracranial metastasis via CTCs. Dual targeting of cellular translation and proliferation …
Proteomic responses in the human dopaminergic LUHMES cell line to imidacloprid and its metabolites imidacloprid-olefin and desnitro-imidacloprid
P Sinclair, J Hakeem, SG Kumar, D Loser… - Pesticide Biochemistry …, 2023 - Elsevier
Neonicotinoids (neonics) are amongst the most commonly used class of pesticides globally.
In the United States, imidacloprid (IMI) is extensively used for agriculture and in other …
In the United States, imidacloprid (IMI) is extensively used for agriculture and in other …
Transcriptome analysis for the screening of hub genes and potential drugs in hypersensitivity pneumonitis
Hypersensitivity pneumonitis (HP), an immune-mediated subtype of interstitial lung diseases
(ILDs), is mediated by repetitive inhalation of certain antigens. Transcriptomic signatures …
(ILDs), is mediated by repetitive inhalation of certain antigens. Transcriptomic signatures …
Genomic hallmarks and therapeutic targets of ribosome biogenesis in cancer
Y Zang, X Ran, J Yuan, H Wu, Y Wang… - Briefings in …, 2024 - academic.oup.com
Hyperactive ribosome biogenesis (RiboSis) fuels unrestricted cell proliferation, whereas
genomic hallmarks and therapeutic targets of RiboSis in cancers remain elusive, and …
genomic hallmarks and therapeutic targets of RiboSis in cancers remain elusive, and …