Unwinding circular RNA's role in inflammatory pulmonary diseases

AA Bhat, G Gupta, A Goyal, R Thapa… - Naunyn-Schmiedeberg's …, 2024 - Springer
Circular RNAs (circRNAs) have emerged as pivotal regulators of gene expression and
cellular processes in various physiological and pathological conditions. In recent years …

Role of mammalian target of rapamycin (mTOR) signalling in oncogenesis

M El-Tanani, H Nsairat, AA Aljabali, Á Serrano-Aroca… - Life Sciences, 2023 - Elsevier
The signalling system known as mammalian target of rapamycin (mTOR) is believed to be
required for several biological activities involving cell proliferation. The serine-threonine …

Protein neddylation and its role in health and diseases

S Zhang, Q Yu, Z Li, Y Zhao, Y Sun - Signal Transduction and Targeted …, 2024 - nature.com
NEDD8 (Neural precursor cell expressed developmentally downregulated protein 8) is an
ubiquitin-like protein that is covalently attached to a lysine residue of a protein substrate …

In-depth metaproteomics analysis of tongue coating for gastric cancer: a multicenter diagnostic research study

J Chen, Y Sun, J Li, M Lyu, L Yuan, J Sun, S Chen… - Microbiome, 2024 - Springer
Background Our previous study revealed marked differences in tongue images between
individuals with gastric cancer and those without gastric cancer. However, the biological …

Hypoxia-induced transcriptional stress is mediated by ROS-induced R-loops

TS Ma, KR Worth, C Maher, N Ng, C Beghè… - Nucleic acids …, 2023 - academic.oup.com
Hypoxia is a common feature of solid tumors and is associated with poor patient prognosis,
therapy resistance and metastasis. Radiobiological hypoxia (< 0.1% O2) is one of the few …

Noncoding RNA Contribution to Aging and Lifespan

AP Ugalde, D Roiz-Valle… - The Journals of …, 2024 - academic.oup.com
Aging is a multifactorial process characterized by an age-related decline in organismal
fitness. This deterioration is the major risk factor for chronic diseases such as cardiovascular …

Targeting Translation and the Cell Cycle Inversely Affects CTC Metabolism but Not Metastasis

TY Bowley, SD Merkley, IV Lagutina, MC Ortiz, M Lee… - Cancers, 2023 - mdpi.com
Simple Summary This study identifies specific ribosomal proteins that drive MBM and
extracranial metastasis via CTCs. Dual targeting of cellular translation and proliferation …

Proteomic responses in the human dopaminergic LUHMES cell line to imidacloprid and its metabolites imidacloprid-olefin and desnitro-imidacloprid

P Sinclair, J Hakeem, SG Kumar, D Loser… - Pesticide Biochemistry …, 2023 - Elsevier
Neonicotinoids (neonics) are amongst the most commonly used class of pesticides globally.
In the United States, imidacloprid (IMI) is extensively used for agriculture and in other …

Transcriptome analysis for the screening of hub genes and potential drugs in hypersensitivity pneumonitis

S Dasgupta, SS Das, A Kar, P Choudhury, I Mitra… - Human Gene, 2023 - Elsevier
Hypersensitivity pneumonitis (HP), an immune-mediated subtype of interstitial lung diseases
(ILDs), is mediated by repetitive inhalation of certain antigens. Transcriptomic signatures …

Genomic hallmarks and therapeutic targets of ribosome biogenesis in cancer

Y Zang, X Ran, J Yuan, H Wu, Y Wang… - Briefings in …, 2024 - academic.oup.com
Hyperactive ribosome biogenesis (RiboSis) fuels unrestricted cell proliferation, whereas
genomic hallmarks and therapeutic targets of RiboSis in cancers remain elusive, and …