The renin angiotensin system (RAS) is intricately involved in normal cardiovascular
homeostasis. Excessive stimulation by the octapeptide angiotensin II contributes to a range …

Autocrine, paracrine, endocrine, and neuroendocrine hormonal systems help regulate
cardio‐vascular and renal function. Any change in the balance among these systems may …

We explored the mechanisms underlying the close association between hypertension and
insulin resistance by measuring the changes in the plasma levels of adiponectin, a novel …

Angiotensin II (Ang II) has a significant role in regulating cardiac homeostasis through
humoral, autocrine and paracrine pathways, via binding to the plasma membrane AT1 …

Cardiomyopathies represent an important cause of cardiovascular morbidity and mortality
due to heart failure, arrhythmias, and sudden death. A majority of hypertrophic …

Unveiling the mechanism of action of a drug is key to understand the benefits and adverse
reactions of a medication in an organism. However, in complex diseases such as heart …

Angiotensin II has emerged as an important growth factor for vascular, cardiac, and renal
cells. Depending on the specific cell type and presence of other growth factors, angiotensin …

Aims Heart growth and function are angiogenesis-dependent, but little is known concerning
the effects of key regulators of angiogenesis on diastolic heart failure. Here, we tested the …

Angiotensin II (ANG II) induces cell-cycle arrest of cultured proximal tubular cells, resulting in
cellular hypertrophy. This ANG II-mediated hypertrophy is associated with the induction of …

Background Activation of the renin-angiotensin-system (RAS) plays a key
pathophysiological role in heart failure in patients with hypertension and myocardial …